PMID: 11322431Apr 27, 2001Paper

Elevation of soluble intercellular adhesion molecule-1 levels in symptomatic and asymptomatic carotid atherosclerosis

Neurosurgery
J MoccoE Sander Connolly

Abstract

Recent data suggest that the increased expression of intercellular adhesion molecule-1 (ICAM-1) in atherosclerotic plaque taken from the carotid bifurcation correlates with the development of neurological symptoms. As a result, the authors sought to compare the serum levels of soluble forms of ICAM-1 (sICAM-1) in patients who were asymptomatic with those who were symptomatic for carotid artery stenosis as well as in patients who were matched in terms of sex, age, and risk factors who did not have carotid artery disease. Using enzyme-linked immunosorbent assay, serum sICAM-1 levels were prospectively determined in 54 patients scheduled to undergo carotid endarterectomy for either symptomatic or asymptomatic high-grade stenosis (> or =60%) and in 5 additional patient controls. Data are expressed as mean +/- standard error of the mean, with significance defined as P < 0.05 using the Mann-Whitney two-tailed test for two-column comparison or analysis of variance and Fisher protected least significant difference test. Using a univariate model, serum sICAM-1 levels were significantly elevated in patients with carotid artery stenosis as compared with control patients without stenosis (347 +/- 15 ng/ml versus 216 +/- 8.2 ng/ml) (P < 0.0...Continue Reading

References

Aug 15, 1991·The New England Journal of Medicine·UNKNOWN North American Symptomatic Carotid Endarterectomy Trial CollaboratorsM Eliasziw
Oct 1, 1995·Journal of Neurotrauma·X Wang, G Z Feuerstein
Dec 1, 1995·Molecular and Chemical Neuropathology·W M ClarkB M Coull
Jan 1, 1997·Stroke; a Journal of Cerebral Circulation·M EndresM Kaps
Nov 22, 1997·Stroke; a Journal of Cerebral Circulation·C J FrijnsR Fijnheer
Oct 2, 1998·Stroke; a Journal of Cerebral Circulation·A BitschP Rieckmann

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Citations

Feb 8, 2013·Biomarkers in Medicine·Lena Rothstein, Glen C Jickling
Mar 6, 2010·Expert Review of Endocrinology & Metabolism·Sridevi DevarajIshwarlal Jialal
Feb 9, 2010·Expert Review of Neurotherapeutics·Nada El Husseini, Daniel T Laskowitz
Feb 11, 2011·Expert Review of Neurotherapeutics·Mira Katan, Mitchell S V Elkind
Nov 22, 2011·Revista Española De Cardiología·Antonio L Arrebola-MorenoJuan Carlos Kaski
Jul 16, 2010·Atherosclerosis·Linda HermusClark J Zeebregts
Apr 13, 2010·Neurosurgery Clinics of North America·J Dedrick Jordan, Paul Nyquist
Jun 16, 2007·Journal of the Neurological Sciences·Ricardo J KomotarE Sander Connolly
Feb 26, 2004·Obesity Research·Ursula Hanusch-EnsererRudolf Prager
Jul 31, 2003·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Kazuko Motohashi, Shingo Yamane
Mar 28, 2012·Annals of Neurology·Dawn N Kernagis, Daniel T Laskowitz
Dec 27, 2005·International Journal of Radiation Oncology, Biology, Physics·Deborah CitrinKevin Camphausen
May 13, 2015·Bioanalysis·Swathi R PullagurlaSteven A Soper
Nov 6, 2007·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·J Golledge, D-A Siew
Jul 3, 2002·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·K RerkasemR F Grimble
Apr 19, 2008·Vascular and Endovascular Surgery·Erik DebingPierre Van den Brande
Mar 5, 2019·Neuromolecular Medicine·Joseph Kamtchum-Tatuene, Glen C Jickling
May 27, 2003·Clinical Chemistry·Pascale G A Van HoydonckElisabeth H M Temme

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