PMID: 3772381Dec 1, 1986Paper

Elevation of striatal dopamine receptors by estrogen: dose and time studies

Journal of Neurochemistry
R E Hruska

Abstract

Administration to male rats of a single dose of 17 beta-estradiol valerate (8-500 micrograms/rat) or implantation of a pellet containing 17 beta-estradiol (0.5-50 mg/rat) increased serum 17 beta-estradiol levels in a dose-dependent relationship when measured on the sixth day after administration. At the same time, after these doses, the serum rat prolactin (rPRL) levels were doubled and the striatal 3,4-dihydroxyphenylethylamine (DA, dopamine) receptor densities were increased 20%. A single dose of 17 beta-estradiol valerate of 4 micrograms/rat or less did not alter serum 17 beta-estradiol or rPRL levels or the striatal DA receptor density. After the single injection of 17 beta-estradiol valerate (125 micrograms/rat) the serum 17 beta-estradiol levels peaked at 1 day, the serum rPRL levels peaked at 2 days, and the striatal DA receptor density elevation peaked from 4 to 8 days. Implantation of a pellet containing 17 beta-estradiol (25 mg/rat) produced a constant elevation of serum 17 beta-estradiol levels from 1 to 10 days. Whereas the serum rPRL levels were continuously elevated about two-fold, the densities of the striatal DA receptors were increased significantly by 20-25% only from 4 to 8 days after pellet implantation. The...Continue Reading

References

Jan 1, 1974·The Journal of Clinical Endocrinology and Metabolism·B G EnglandA R Midgley
Nov 1, 1982·Journal of Neurochemistry·R E Hruska, K T Pitman
Jan 1, 1984·Psychoneuroendocrinology·T Di PaoloF Labrie
Aug 13, 1982·European Journal of Pharmacology·E J RoyM A Wilson
Jan 1, 1982·Progress in Neuro-psychopharmacology & Biological Psychiatry·T Di PaoloF Labrie
Aug 1, 1982·Journal of Neurochemistry·C M PadenV DeGroff
Dec 20, 1982·Life Sciences·T Di PaoloF Labrie
Feb 1, 1980·European Journal of Pharmacology·R E Hruska, E K Silbergeld
Jul 17, 1981·European Journal of Pharmacology·T Di PaoloF Labrie
Feb 1, 1982·Pharmacology, Biochemistry, and Behavior·R E HruskaE K Silbergeld

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Citations

Jan 1, 1991·Journal of Neural Transmission. General Section·M L HernándezJ A Ramos
Jan 1, 1991·Journal of Neural Transmission. General Section·J J Fernández-RuizJ A Ramos
Jan 1, 1994·Journal of Neural Transmission. General Section·M L HernándezJ A Ramos
Jun 1, 1996·Cellular and Molecular Neurobiology·R Alonso-SolísA Hernández
Aug 15, 1993·Biological Psychiatry·N R SwerdlowD L Braff
Jan 1, 1995·Neuroscience and Biobehavioral Reviews·M R Melis, A Argiolas
Jan 11, 1991·Psychoneuroendocrinology·C J HannanS R Plymate
Apr 28, 2001·Pharmacology, Biochemistry, and Behavior·E M ByrnesR S Bridges
Dec 11, 1999·Pharmacology, Biochemistry, and Behavior·J B Becker
May 26, 1999·Behavioural Brain Research·V Quiñones-JenabM J Kreek
Jun 15, 1999·Brain Research. Molecular Brain Research·C H LammersM M Mouradian
Mar 26, 2003·Psychoneuroendocrinology·H Häfner
Jul 15, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Laura DazziGiovanni Biggio
Jan 11, 2005·Neuroreport·Jill L SharifiJames I Koenig
May 31, 1994·Annals of the New York Academy of Sciences·G S Roth, J A Joseph
Dec 14, 2011·Autoimmunity Reviews·Sabine Oertelt-Prigione
Feb 16, 2008·Pharmacology, Biochemistry, and Behavior·Sarah L ParylakCynthia M Kuhn
Feb 22, 2005·Brain Research·Sandeep D Bhatt, Dean E Dluzen
Aug 23, 2005·Pharmacology, Biochemistry, and Behavior·Erin B LarsonMarilyn E Carroll
May 28, 2011·Acta Physiologica Hungarica·Julia Fedotova, N Ordyan

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