PMID: 9440545Jan 24, 1998Paper

Elevation of the plasma level of RANTES during asthma attacks

The Journal of Allergy and Clinical Immunology
J ChiharaH Yamada

Abstract

RANTES is considered to play an important role in various immune and allergic disorders since it is a potent chemoattractant for inflammatory cells such as eosinophils, memory T cells, and monocytes. To investigate the possible role of RANTES in the pathogenesis of bronchial asthma. The plasma level of RANTES was measured in 12 asthma patients and 15 normal controls by a sandwich enzyme-linked immunosorbent assay. In the patients with asthma, the plasma RANTES level was significantly elevated during acute attacks compared to that in the controls. In addition, it was higher than that during the asymptomatic state in the same patients. Plasma beta-thromboglobulin levels were also elevated in asthma patients during acute attacks and showed a correlation with the RANTES level. These findings suggest a role for RANTES in the pathogenesis of asthma and a possible role for platelets in RANTES release in asthma.

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Citations

Mar 15, 2001·Thrombosis Research·S Abi-YounesA D Luster
Dec 22, 1998·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·J ChiharaT Yamamoto
Feb 4, 1999·Allergy·J ChiharaO Urayama
Apr 16, 2008·Respirology : Official Journal of the Asian Pacific Society of Respirology·Figen DeveciNusret Akpolat
Aug 24, 1999·Thorax·K F Chung, P J Barnes
Jan 5, 2007·Proceedings of the American Thoracic Society·Nadia N Hansel, Gregory B Diette
Aug 17, 2014·Current Opinion in Pharmacology·Nadine Anna Caterina Landolina, Francesca Levi-Schaffer
Jul 22, 2010·Journal of Pharmacological and Toxicological Methods·Hom N S SaihkayJames R Ballinger
Nov 1, 2006·Allergology International : Official Journal of the Japanese Society of Allergology·Hajime OyamadaJunichi Chihara
Dec 3, 2011·Respiratory Medicine·Esra BirbenOmer Kalayci
Jul 19, 2005·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Ioannis MoissidisSami L Bahna
May 17, 2000·Pediatric Research·M F BöttcherR P Garofalo
Jan 29, 2005·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Bülent TutluogluTurgut Ulutin
Nov 1, 2017·PloS One·Elena Marcos-VadilloMaría Isidoro-García
Feb 15, 2001·Nature Cell Biology·M BakhietJ Andersson
Dec 18, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jane M SchuhCory M Hogaboam
Apr 18, 2009·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Chin-Kan ChanJing-Long Huang

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