Elevation of transaminases associated with teriparatide treatment: a case report

European Journal of Hospital Pharmacy. Science and Practice
Francesco PappalardoVincenzo Caruso

Abstract

This report describes the case of a 64-year-old Caucasian woman presenting with hypertransaminasemia during treatment with teriparatide for postmenopausal osteoporosis. The patient was also receiving food supplements containing red yeast rice (RYR) to lower her cholesterol levels. RYR has been reported to cause hepatoxicity because it contains monacolin K. According to the results of a causality assessment, carried out via several probability scales, teriparatide was defined as a 'possible' cause of the adverse drug reaction (ADR). Following progressive normalisation of the levels of transaminases after the teriparatide was discontinued, we therefore postulated that teriparatide was the main cause of the ADR. In addition to this, based on a literature review, we considered RYR as a concomitant agent in the aetiology of the ADR. Further post-marketing surveillance studies on teriparatide seem to be necessary.

References

Feb 24, 2016·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·R LindsayJ J Stepan
Jan 18, 2017·British Journal of Clinical Pharmacology·Gabriela MazzantiFrancesca Menniti-Ippolito
Mar 28, 2018·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Emanuel RaschiFabrizio De Ponti
Aug 9, 2018·Journal of the Endocrine Society·Andrea V Haas, Meryl S LeBoff
Sep 16, 2018·British Journal of Clinical Pharmacology·Gaia Tabacco, John P Bilezikian
Sep 22, 2018·Journal of Bone Metabolism·Bente Lomholt Langdahl, Jane Dahl Andersen
Mar 27, 2019·BMJ Case Reports·Lize LoubserSean M Drake

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