Elevations of nucleus accumbens dopamine and DOPAC levels during intravenous heroin self-administration

Synapse
R A WiseK Leeb

Abstract

Extracellular dopamine and DOPAC (3,4-dihydroxyphenylacetic acid) levels in nucleus accumbens were sampled by microdialysis and quantified with high-performance liquid chromatography during intravenous heroin self-administration sessions in rats. Dopamine levels in 10 and 20 min samples were elevated following the first injection of each session, reaching a plateau of elevation within the first two or three injections and falling back toward baseline only when drug access was terminated. Elevations were in the range of 150-300% when unit dosages of 0.05-0.2 mg/kg were given. Increasing the work requirement from FR-1 to FR-10 did not appear to alter the degree of elevation of dopamine levels, and dopamine levels fell during extinction while lever-pressing rates increased 20-fold. While animals compensated for unit dose changes between 0.05 and 0.2 mg/kg/injection, adjusting their response rate such that the same hourly drug intake and the same asymptotic dopamine levels were maintained across these conditions, at 0.4 mg/kg/injection hourly drug intake and asymptotic dopamine levels were elevated beyond the levels sustained by the lower doses. These findings confirm that self-administered doses of intravenous heroin are sufficien...Continue Reading

References

Oct 1, 1976·Pharmacology, Biochemistry, and Behavior·M Risner, B E Jones
Jan 1, 1992·Canadian Journal of Physiology and Pharmacology·R A Swanson
Jun 28, 1992·Annals of the New York Academy of Sciences·T S ShippenbergC Stein
Mar 3, 1992·European Journal of Pharmacology·A ImperatoS Puglisi-Allegra
Jul 8, 1992·Annals of the New York Academy of Sciences·R A WiseW Trojniar
Jan 25, 1991·European Journal of Pharmacology·E AcquasG Di Chiara
Jun 1, 1991·Pharmacology, Biochemistry, and Behavior·P LeoneR A Wise
Jul 18, 1989·European Journal of Pharmacology·Y L Hurd, U Ungerstedt
Jan 1, 1989·Neuroscience and Biobehavioral Reviews·R A Wise
Dec 1, 1989·Pharmacology, Biochemistry, and Behavior·H O Pettit, J B Justice
Jan 1, 1985·Neuroscience and Biobehavioral Reviews·C A Dackis, M S Gold
Nov 1, 1987·Naunyn-Schmiedeberg's Archives of Pharmacology·B H WesterinkJ B de Vries
Dec 1, 1985·Pharmacology, Biochemistry, and Behavior·K A ZitoD C Roberts
Jan 1, 1969·Psychopharmacologia·G DeneauM H Seevers
Oct 24, 1983·Brain Research·K Gysling, R Y Wang
Mar 1, 1984·Pharmacology, Biochemistry, and Behavior·N E GoedersJ E Smith
Jan 1, 1983·Psychopharmacology·B G HoebelL Lenard
Jan 1, 1980·Psychopharmacology·M E Risner, B E Jones
Aug 19, 1983·Science·N E Goeders, J E Smith
Jan 1, 1980·Pharmacology, Biochemistry, and Behavior·J M van Ree, D de Wied
Apr 15, 1982·Brain Research·M E Olds

❮ Previous
Next ❯

Citations

May 14, 2009·Psychopharmacology·Tommy PattijAnton N M Schoffelmeer
Dec 21, 2000·Current Psychiatry Reports·S E Hemby
May 21, 2005·Alcohol·Nicole M AvenaBartley G Hoebel
Apr 20, 2000·European Journal of Pharmacology·G Di Chiara
Nov 21, 1996·European Journal of Pharmacology·M NurmiK Kiianmaa
Aug 12, 1999·European Journal of Pharmacology·G Di Chiara
Feb 7, 2002·Pharmacology, Biochemistry, and Behavior·Ronald E See
Apr 2, 2003·Pharmacology, Biochemistry, and Behavior·Caren L SteinmillerStanley D Glick
Jul 23, 2003·Pharmacology, Biochemistry, and Behavior·Charles D Cook, Patrick M Beardsley
Dec 22, 1998·Brain Research. Brain Research Reviews·K C Berridge, T E Robinson
Nov 26, 2002·Behavioural Brain Research·Gaetano Di Chiara
Dec 15, 2000·Progress in Neurobiology·T M Tzschentke
Jun 14, 2000·Progress in Neurobiology·I J MitchellM R Griffiths
Apr 1, 1996·Current Opinion in Neurobiology·R A Wise
Jul 30, 2008·The Behavioral and Brain Sciences·A David RedishAdam Johnson
Sep 22, 2005·Experimental and Clinical Psychopharmacology·Frances K McSweeneyBenjamin P Kowal
Sep 12, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Yong ZhangMary Jeanne Kreek
Jun 14, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Anna K Radke, Jonathan C Gewirtz
Oct 15, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Roy A Wise, George F Koob
Oct 6, 2011·Nature Reviews. Neuroscience·Aldo BadianiYavin Shaham
Jun 16, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·James E SmithThomas J Martin
Aug 27, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Stéphanie Caillé, Loren H Parsons
May 20, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Dawn N AlbertsonMichael J Bannon
Nov 13, 2001·The European Journal of Neuroscience·C Martin-SoelchK L Leenders
Dec 21, 2002·Addiction·Francesco LeriJane Stewart
Aug 1, 2006·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Roy A Wise
Dec 3, 1998·Alcoholism, Clinical and Experimental Research·M NurmiK Kiianmaa

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.