Eleven-year outcome of patients with prostate cancers diagnosed during screening after initial negative sextant biopsies

European Urology
Fritz H SchröderMonique J Roobol

Abstract

The appropriate way of biopsying a prostate remains controversial. Is sextant biopsy still adequate with repeat screening? Within the European Randomized Study of Screening for Prostate Cancer (ERSPC), lateralized sextant biopsies were applied. In this analysis we use distant end points to study the fate of prostate cancers (PCa) potentially missed by initial biopsies. This retrospective study included 19 970 men ages 55-74 identified from the Rotterdam population registry and screened repeatedly for PCa between 1993 and 2005. PCa detected later in men with initially negative biopsies were considered as missed. Rescreening every 4 yr and a complete follow-up of 11 yr allowed an inventory of progressive and deadly disease in these men. Sextant biopsies initially, later lateralized, in screen-positive men. The fate of PCa potentially missed by initial sextant biopsies in terms of progression-free and PCa-specific survival were the main outcome measures. Kaplan-Meier analysis was used to evaluate differences between subgroups. In 3056 men with negative biopsies at the first screen, 287 PCa were subsequently detected. Of these 287 cases, 26 developed progressive disease and 7 died of PCa. Poor outcomes were encountered mainly in 20...Continue Reading

References

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Citations

Aug 20, 2010·The New England Journal of Medicine·Lambertus A Kiemeney, Maarten C Bosland
Apr 22, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Caroline J SavageAndrew J Vickers
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Oct 26, 2011·European Urology·Bobby B NajariFelix K Chun
Nov 16, 2010·The Journal of Urology·Yuanyuan LiangIan M Thompson
Nov 29, 2015·The Urologic Clinics of North America·Michelle L McDonald, J Kellogg Parsons
Feb 1, 2012·BJU International·Pim J van LeeuwenFritz H Schröder
Sep 15, 2010·Cancer·Pim J van LeeuwenAnna Gavin
Mar 31, 2011·International Journal of Cancer. Journal International Du Cancer·Xiaoye ZhuFritz H Schröder
Dec 18, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Heidi A van VugtEwout W Steyerberg
Mar 12, 2011·Nature Reviews. Urology·Sheng Fei OonR William G Watson
May 22, 2010·Current Opinion in Supportive and Palliative Care·Xiaoye ZhuFritz H Schröder
Jul 22, 2010·Expert Review of Anticancer Therapy·Heidi A van VugtMonique J Roobol
Sep 17, 2010·The New England Journal of Medicine·Laurence Klotz
May 27, 2011·Acta Oncologica·Meelan Bul, Fritz H Schröder
Aug 13, 2010·Current Opinion in Supportive and Palliative Care

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