Eleven years' experience with Intrathecal Baclofen - Complications, risk factors

Brain and Behavior
Elke Pucks-FaesL Saltuari

Abstract

Treatment with intrathecal baclofen (ITB) is commonly used in patients with severe spasticity. However, complications may occur after implantation of the ITB-device, albeit mainly procedure- and device-related problems. The aim of the study was to assess surgical- as well as catheter- and pump-related complications and define their risk factors. We retrospectively evaluated all patients with an implanted ITB-device who were treated at the Department of Neurology, Hochzirl Hospital, Zirl, Austria, between 2006 and 2016. Twenty-nine of 116 (25%) patients experienced 32 complications: 5 procedure- and 27 device-related (4 pump- and 23 catheter-associated) problems occurred. Risk factors for sustaining any complication were a spinal localization of lesion (odds ratio [OR] OR 2.71, p = .021), other catheter types than an Ascenda® catheter (OR 3.87, p = .041), a lower modified Rankin Scale (median 4 vs. 5; OR 2.86, p = .015) and a higher Barthel Index (median 53 vs. 0; OR 2.84, p = .006). The median time from the last ITB-related surgery to the first complication was 18 (IQR 1-57) months. Overall, 47% complications occurred within the first year after any surgical procedure regarding the ITB-device, thereof 25% within the first month...Continue Reading

References

Jun 8, 1989·The New England Journal of Medicine·R D PennJ S Kroin
Jul 20, 1985·Lancet·R D Penn, J S Kroin
May 1, 1996·Archives of Physical Medicine and Rehabilitation·J M MeythalerM Hadley
Jan 14, 1999·Journal of Neurology, Neurosurgery, and Psychiatry·R BeckerH Bertalanffy
Jan 23, 1999·Archives of Physical Medicine and Rehabilitation·J M MeythalerM N Hadley
Mar 21, 2002·Acta Neurologica Scandinavica·A DarioG Bono
Apr 22, 2004·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Tony L YakshRobert J Coffey
Jan 28, 2005·The Journal of Neuroscience Nursing : Journal of the American Association of Neuroscience Nurses·Patrice Korth Rawlins
Nov 8, 2005·Archives of Physical Medicine and Rehabilitation·Daniel GuillaumeGeir Roeste
May 2, 2012·ISRN Neurology·Yasser AwaadG Michael Waines
Jan 11, 2014·Journal of Neurosurgery. Pediatrics·Francesco Motta, Clara E Antonello
Jan 11, 2014·Archives of Physical Medicine and Rehabilitation·Léo BorriniClaire Jourdan
Jun 25, 2016·Journal of Neurosurgery. Pediatrics·Francesco Motta, Clara Eleonora Antonello
Aug 10, 2016·Neuromodulation : Journal of the International Neuromodulation Society·I Elias VeiziTony Yaksh
Mar 16, 2017·Zhurnal voprosy neĭrokhirurgii imeni N. N. Burdenko·D L PaskhinE M Salova

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Citations

Aug 11, 2019·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Christian HagemannPhilip Kunkel
Feb 6, 2021·Archives of Rehabilitation Research and Clinical Translation·Elke Pucks-FaesLeopold Saltuari
May 12, 2021·Neuromodulation : Journal of the International Neuromodulation Society·Christina N FellerPeter A Pahapill
Feb 6, 2021·PM & R : the Journal of Injury, Function, and Rehabilitation·Rachel BlueH Isaac Chen
Jul 16, 2021·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Ajay PatelJeffrey S Raskin

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