Elg1, a central player in genome stability

Mutation Research. Reviews in Mutation Research
Inbal GazyMartin Kupiec

Abstract

ELG1 is a conserved gene uncovered in a number of genetic screens in yeast aimed at identifying factors important in the maintenance of genome stability. Elg1's activity prevents gross chromosomal rearrangements, maintains proper telomere length regulation, helps repairing DNA damage created by a number of genotoxins and participates in sister chromatid cohesion. Elg1 is evolutionarily conserved, and its mammalian ortholog (also known as ATAD5) is embryonic lethal when lost in mice, acts as a tumor suppressor in mice and humans, exhibits physical interactions with components of the human Fanconi Anemia pathway and may be responsible for some of the phenotypes associated with neurofibromatosis. In this review, we summarize the information available on Elg1-related activities in yeast and mammals, and present models to explain how the different phenotypes observed in the absence of Elg1 activity are related.

References

Dec 1, 1992·Molecular and Cellular Biology·N KouprinaF Spencer
Feb 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·J Miles, T Formosa
Jan 1, 1997·Genes & Development·S Strahl-BolsingerM Grunstein
Jun 9, 1997·Mutation Research·M Kupiec, R Steinlauf
Jan 4, 2001·Current Biology : CB·S PanizzaK Nasmyth
Apr 5, 2001·Molecular and Cellular Biology·J S HannaF A Spencer
Sep 27, 2001·Proceedings of the National Academy of Sciences of the United States of America·L A Lindsey-BoltzA Sancar
Oct 5, 2001·Molecular Cell·D Moazed
Mar 28, 2002·Proceedings of the National Academy of Sciences of the United States of America·Kyungjae Myung, Richard D Kolodner
Nov 14, 2002·Annual Review of Genetics·Kara A NybergTed A Weinert
Jan 31, 2003·Molecular and Cellular Biology·Yael AylonMartin Kupiec
Feb 27, 2003·Proceedings of the National Academy of Sciences of the United States of America·Jerzy Majka, Peter M J Burgers
May 16, 2003·Nature·Lumir KrejciPatrick Sung
Aug 12, 2003·Proceedings of the National Academy of Sciences of the United States of America·Shay Ben-AroyaMartin Kupiec
Aug 13, 2003·The EMBO Journal·Mohammed BellaouiGrant W Brown
Sep 16, 2003·Proceedings of the National Academy of Sciences of the United States of America·Meng-Er HuangRichard D Kolodner
Sep 19, 2003·Current Biology : CB·Pamela KanellisDaniel Durocher
Jan 27, 2004·Molecular Biology of the Cell·Melanie L MayerPhilip Hieter
Jan 28, 2004·Proceedings of the National Academy of Sciences of the United States of America·Sarit SmolikovAnat Krauskopf
May 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·Syed H AskreeMichael J McEachern
Jun 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·Stephanie SmithKyungjaem Myung
Jul 29, 2004·DNA Repair·Yael Aylon, Martin Kupiec
Oct 30, 2004·Proceedings of the National Academy of Sciences of the United States of America·Kyungjae MyungRichard D Kolodner
Nov 5, 2004·Molecular Cell·Xuewen PanJef D Boeke
Feb 8, 2005·Molecular Cell·Sebastian M B NijmanRené Bernards
Feb 24, 2005·DNA Repair·Shay Ben Aroya, Martin Kupiec
Mar 9, 2005·Cell Cycle·Lena Ström, Camilla Sjögren
Jun 3, 2005·Nature·Boris PfanderStefan Jentsch
Jun 21, 2005·Molecular and Cellular Biology·Göran O Bylund, Peter M J Burgers
Jun 29, 2005·Proceedings of the National Academy of Sciences of the United States of America·Hideshi IshiiYusuke Furukawa

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Citations

Jul 16, 2015·Cell Cycle·Dganit ShkedyMartin Kupiec
Aug 21, 2015·Cell Cycle·Marek Sebesta, Lumir Krejci
Oct 23, 2016·FEMS Yeast Research·Martin Kupiec
Feb 15, 2018·Proceedings of the National Academy of Sciences of the United States of America·Ryan JankeJasper Rine
Apr 17, 2020·Nucleic Acids Research·Sara GiovanniniJosef Jiricny
Feb 19, 2017·Human Genetics·Hildegard Kehrer-SawatzkiDavid N Cooper
Dec 20, 2020·Experimental & Molecular Medicine·Kyoo-Young Lee, Su Hyung Park

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