Elicitation as a tool to improve the profiles of high-value secondary metabolites and pharmacological properties of Hypericum perforatum

The Journal of Pharmacy and Pharmacology
Preeti ShakyaGregory Franklin

Abstract

In this review, we aim at updating the available information on the improvement of the Hypericum perforatum L. (Hypericaceae) phytochemical profile and pharmacological properties via elicitation. Hypericum perforatum seedlings, shoots, roots, calli and cell suspension cultures were treated with diverse elicitors to induce the formation of secondary metabolites. The extracts of the elicitor-treated plant material containing naphthodianthrones, phloroglucinols, xanthones, flavonoids and other new compounds were quantitatively analysed and tested for their bioactivities. While hypericins were mainly produced in H. perforatum cultures containing dark nodules, namely shoots and seedlings, other classes of compounds such as xanthones, phloroglucinols and flavonoids were formed in all types of cultures. The extracts obtained from elicitor-treated samples generally possessed better bioactivities compared to the extract of control biomass. Although elicitation is an excellent tool for the production of valuable secondary metabolites in H. perforatum cell and tissue cultures, its exploitation is still in its infancy mainly due to the lack of reproducibility and difficulties in scaling up biomass production.

References

Mar 6, 1999·Current Opinion in Plant Biology·A J Trewavas, R Malhó
Jun 23, 1999·The Plant Journal : for Cell and Molecular Biology·G FelixT Boller
Jun 5, 2002·The Plant Cell·Zhenbiao Yang
Aug 17, 2002·Current Opinion in Plant Biology·Xuemin Wang
Jul 1, 1995·The Plant Cell·R. A. Dixon, N. L. Paiva
Sep 1, 1994·The Plant Cell·H. D. VanEttenE. E. Farmer
Aug 23, 2003·Annals of Botany·Philip J White, Martin R Broadley
Sep 25, 2003·Annual Review of Plant Biology·Harold J G Meijer, Teun Munnik
Oct 11, 2003·Biotechnology Advances·S R Rao, G A Ravishankar
Feb 5, 2004·Phytochemistry·Anna PiovanElsa Mariella Cappelletti
Feb 17, 2005·Journal of Agricultural and Food Chemistry·Renato BruniAlberto Bianchi
Apr 26, 2005·Biotechnology Advances·Jian ZhaoRobert Verpoorte
Jun 28, 2005·Plant Physiology and Biochemistry : PPB·Sonja GadzovskaDaniel Hagège
Mar 24, 2006·Fitoterapia·Bruno TirilliniSimona Sighinolfi
Nov 17, 2006·Nature·Jonathan D G Jones, Jeffery L Dangl
Jan 2, 2007·Phytochemistry·Evangelos C TatsisIoannis P Gerothanassis
Jul 1, 2008·Current Opinion in Plant Biology·Saskia C M Van WeesCorné M J Pieterse
Feb 14, 2009·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Renato Bruni, Gianni Sacchetti
Jan 14, 2010·The Journal of Clinical Psychiatry·Richard C Shelton
Jan 30, 2010·International Journal of Molecular Sciences·Rocío González-LamotheKamal Bouarab
Jul 24, 2010·Annual Review of Genetics·Jianqiang Wu, Ian T Baldwin
Feb 1, 2011·Photochemistry and Photobiology·Melissa L BrechnerLeslie A Weston
Jul 26, 2011·Trends in Plant Science·Uwe Conrath
Nov 2, 2011·Plant Signaling & Behavior·Akula Ramakrishna, Gokare Aswathanarayana Ravishankar
Nov 30, 2011·Annals of Biomedical Engineering·Malini OlivoWeber Kam On Lau
Sep 15, 2012·Trends in Plant Science·Marie Boudsocq, Jen Sheen
Jan 12, 2013·Journal of Experimental Botany·Yuriko OsakabeLam-Son Phan Tran

❮ Previous
Next ❯

Citations

Apr 25, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Andrea BalažováPavel Mučaji
Apr 14, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Urszula ZłotekAnna Jakubczyk
Sep 27, 2019·Mini Reviews in Medicinal Chemistry·Mariangela MarrelliFilomena Conforti
Apr 21, 2020·Biotechnology & Genetic Engineering Reviews·Melissa Yit Yee Kam, Winnie Soo Ping Yap
Dec 12, 2018·The Journal of Pharmacy and Pharmacology·Joanne BarnesBasil D Roufogalis
Mar 30, 2020·Applied Microbiology and Biotechnology·Zhangqing SongXiaoping Yu
Oct 20, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ewa KochanMonika Sienkiewicz
Oct 18, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jameel Mohammed Al-Khayri, Poornananda Madhava Naik
Mar 16, 2021·Engineering in Life Sciences·Geraldine GubserRegine Eibl
Oct 6, 2021·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Sagar S AryaJames E Rookes

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved