Eliciting B cell immunity against infectious diseases using nanovaccines

Nature Nanotechnology
Ankur Singh

Abstract

Infectious diseases, including the coronavirus disease 2019 (COVID-19) pandemic that has brought the world to a standstill, are emerging at an unprecedented rate with a substantial impact on public health and global economies. For many life-threatening global infectious diseases, such as human immunodeficiency virus (HIV) infection, malaria and influenza, effective vaccinations are still lacking. There are numerous roadblocks to developing new vaccines, including a limited understanding of immune correlates of protection to these global infections. To induce a reproducible, strong immune response against difficult pathogens, sophisticated nanovaccine technologies are under investigation. In contrast to conventional vaccines, nanovaccines provide improved access to lymph nodes, optimal packing and presentation of antigens, and induction of a persistent immune response. This Review provides a perspective on the global trends in emerging nanoscale vaccines for infectious diseases and describes the biological, experimental and logistical problems associated with their development, and how immunoengineering can be leveraged to overcome these challenges.

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Citations

Apr 20, 2021·Frontiers in Immunology·Domenick E Kennedy, Marcus R Clark
May 8, 2021·Experimental Biology and Medicine·Noah Trac, Eun Ji Chung
Jun 1, 2021·ACS Central Science·Yingzhu LiQiongqiong Zhou
Aug 7, 2021·Molecular Aspects of Medicine·Jiarong ZhouLiangfang Zhang
Aug 1, 2021·Journal of Biomedical Materials Research. Part a·Feiyang CaiXing Jiang
Aug 27, 2021·Nature Reviews. Drug Discovery·Namit ChaudharyKathryn A Whitehead
Aug 30, 2021·Trends in Pharmacological Sciences·Shruthi Polla RaviArghya Paul

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Methods Mentioned

BETA
glycosylation
PLGA

Clinical Trials Mentioned

NCT03186781

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