Eliciting the T cell fate with Notch.

Seminars in Immunology
Dil Afroz SultanaAvinash Bhandoola

Abstract

Multipotent progenitors arrive at the thymus via the blood. Constraining the non-T cell fates of these progenitors while promoting the T cell fate is a major task of the thymus. Notch appears to be the initial trigger for a developmental program that eventually results in T cell lineage commitment. Several downstream targets of Notch are known, but the specific roles of each are poorly understood. A greater understanding of how Notch and other thymic signals direct progenitors to a T cell fate could be useful for translational work. For example, such work could eventually allow for the generation of fully competent T cells in vitro that could supplement the waning T cell numbers and function in the elderly and boost T cell-mediated immunity in patients with immunodeficiency and after stem cell transplantation.

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Citations

Nov 29, 2011·Experimental Brain Research·Johannes ProxPaul Saftig
Dec 28, 2010·The Journal of Allergy and Clinical Immunology·Itai M PessachLuigi D Notarangelo
Jul 27, 2010·Seminars in Immunology·Alfred Singer
Jan 22, 2015·Blood·Ofir Wolach, Richard M Stone
Nov 24, 2011·Proceedings of the National Academy of Sciences of the United States of America·Kristine GermarFotini Gounari
Jun 12, 2013·Nature Methods·Vanessa RedeckeHans Häcker
Sep 21, 2011·Expert Review of Anticancer Therapy·Leonor M Sarmento, João T Barata
Mar 31, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Dil Afroz SultanaAvinash Bhandoola
Jul 15, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Steven A SchaffertChang-Zheng Chen
Nov 18, 2019·Trends in Immunology·Dinesh RaghuLisa A Mielke

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