Eligibility criteria for biologic disease-modifying antirheumatic drugs in axial spondyloarthritis: going beyond BASDAI.

RMD Open
Jose MaronaSofia Ramiro

Abstract

To compare definitions of high disease activity of the Ankylosing Spondylitis Disease Activity Score (ASDAS) and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) in selecting patients for treatment with biologic disease-modifying antirheumatic drugs (bDMARDs). Patients from Rheumatic Diseases Portuguese Register (Reuma.pt) with a clinical diagnosis of axial spondyloarthritis (axSpA) were included. Four subgroups (cross-tabulation between ASDAS (≥2.1) and BASDAI (≥4) definitions of high disease activity) were compared regarding baseline characteristics and response to bDMARDs at 3 and 6 months estimated in multivariable regression models. Of the 594 patients included, the majority (82%) had both BASDAI≥4 and ASDAS ≥2.1. The frequency of ASDAS ≥2.1, if BASDAI<4 was much larger than the opposite (ie, ASDAS <2.1, if BASDAI≥4): 62% vs 0.8%. Compared to patients fulfilling both definitions, those with ASDAS ≥2.1 only were more likely to be male (77% vs 51%), human leucocyte antigen B27 positive (79% vs 65%) and have a higher C reactive protein (2.9 (SD 3.5) vs 2.1 (2.9)). Among bDMARD-treated patients (n=359), responses across subgroups were globally overlapping, except for the most 'stringent' outcomes. Patients captured ...Continue Reading

References

Feb 9, 2006·Annals of the Rheumatic Diseases·T PhamD van der Heijde
Jul 16, 2008·Annals of the Rheumatic Diseases·C LukasUNKNOWN Assessment of SpondyloArthritis international Society
Dec 9, 2008·Annals of the Rheumatic Diseases·D van der HeijdeUNKNOWN Assessment of SpondyloArthritis international Society (ASAS)
Nov 12, 2010·Annals of the Rheumatic Diseases·Pedro MachadoUNKNOWN Assessment of SpondyloArthritis international Society
Apr 27, 2011·Current Opinion in Rheumatology·Pedro Machado, Désirée van der Heijde
Jun 26, 2013·Nature Reviews. Rheumatology·Pedro Machado, Robert Landewé
Jul 6, 2014·Clinical Rheumatology·Gamze KılıçSalih Ozgöçmen
Jun 13, 2015·Current Rheumatology Reports·Robert Landewé, Astrid van Tubergen
Jan 15, 2017·Annals of the Rheumatic Diseases·Désirée van der HeijdeJürgen Braun
Feb 18, 2018·Annals of the Rheumatic Diseases·Pedro M MachadoUNKNOWN Assessment of SpondyloArthritis international Society (ASAS)

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Software Mentioned

BASDAI
ASDAS
Reuma

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