Eligibility for active surveillance and pathological outcomes for men undergoing radical prostatectomy in a large, community based cohort

The Journal of Urology
Marc C SmaldoneBenjamin J Davies

Abstract

We analyzed competing active surveillance criteria in men who underwent radical prostatectomy in relation to outcome data in a large, community based cohort. We identified all men from the CaPSURE database who underwent radical prostatectomy from 1999 to 2007 and met inclusion criteria for the stringent prospective University of California-San Francisco and Johns Hopkins active surveillance protocols. Rates of pathological upgrading, up staging and biochemical recurrence were compared. We identified 2,837 men who underwent radical prostatectomy and had complete pathological and followup data available. Of these men 1,375 and 125 met University of California-San Francisco and Johns Hopkins criteria, respectively. When comparing men who met the 2 sets of criteria vs those who met University of California-San Francisco criteria only, there were no significant differences in the rate of upgrading (20% vs 27%, p = 0.07) and up staging (6% vs 8%, p = 0.39) at radical prostatectomy. At a median 36-month followup 5-year biochemical recurrence-free estimates were similar at 92% in men who met the 2 sets of criteria and 90% in those who met the University of California-San Francisco definition only. On multivariate analysis upgrading to ...Continue Reading

References

Feb 17, 2001·International Journal of Cancer. Journal International Du Cancer·C R King
Nov 25, 2003·The Journal of Urology·Maxwell V MengPeter R Carroll
Mar 17, 2004·The Journal of Urology·Manish I PatelPeter T Scardino
Apr 21, 2005·BJU International·Claire HardieDavid Dearnaley
Mar 2, 2006·Journal of the National Cancer Institute·Christopher WarlickH Ballentine Carter
Mar 7, 2006·The Journal of Urology·Stephen J FreedlandUNKNOWN SEARCH Database Study Group
Jul 24, 2007·The Journal of Urology·Matthew R CooperbergPeter R Carroll
Oct 16, 2007·The Journal of Urology·H Ballentine CarterJonathan I Epstein
Dec 18, 2007·European Urology·Claudio JeldresPierre I Karakiewicz
Apr 4, 2008·Journal of Preventive Medicine and Public Health = Yebang Ŭihakhoe Chi·Hai-Rim Shin
Feb 24, 2009·The Journal of Urology·Simon L ContiPeter R Carroll

❮ Previous
Next ❯

Citations

Jun 28, 2011·International Urology and Nephrology·Prasanna SooriakumaranAshutosh Tewari
Dec 1, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Matthew R CooperbergPeter R Carroll
Mar 29, 2014·Journal of Cancer Research and Clinical Oncology·Teruo InamotoUNKNOWN Japan Study Group of Prostate Cancer (J-CaP)
Jun 16, 2012·European Urology·Marc A Dall'EraMark S Soloway
Jun 23, 2011·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·F StaermanUNKNOWN CCAFU
Mar 12, 2013·European Urology·Elizabeth D SelvaduraiChris C Parker
Mar 20, 2014·The Journal of Urology·Al B BarqawiE David Crawford
Nov 2, 2016·Prostate Cancer and Prostatic Diseases·M A Dall'Era, L Klotz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.