Eliminating Hepatitis C Virus From a Prevalent Kidney Transplant Recipient Population: A Single-Center Study in Belgium in the Direct-Acting Antivirals Era

Transplantation Proceedings
Arnaud DevresseNada Kanaan

Abstract

Direct-acting antivirals (DAAs) have revolutionized the treatment of hepatitis C virus (HCV) infection. Although previous studies have reported positive results with DAAs after kidney transplantation (KT), their impact on the prevalence of HCV viremia (HCVv) in prevalent kidney transplant recipients (KTRs) remains ill defined. We retrospectively reviewed the HCV status of all patients followed at Cliniques Universitaires Saint-Luc, Brussels, Belgium, outpatient KT clinic between January 2014 and December 2018. We collected the clinical features of KTRs treated with DAAs during this period and calculated the annual prevalence of HCVv over this period. Out of 1451 KTRs, 22 (1.52%) had HCVv in 2014 to 2018. From 2014 to 2018, the annual prevalence of HCVv dropped from 1.97% to 0.43%, (P < .001). Fourteen KTRs were treated with DAAs a median of 197 months (range: 5-374) after KT, mostly (79%) in 2017 after reimbursement restrictions of DAAs for KTRs in Belgium were removed. DAA treatment was safe with a sustained virological response rate at 12 weeks after treatment (SVR12) of 93%. Two patients died 14 months (lymphoma, despite SVR12) and 7 months (hepatocarcinoma, no SVR12) after DAAs initiation, respectively. Among HCVv KTRs not ...Continue Reading

References

Sep 16, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Fabrizio FabriziGareth Dulai
Oct 20, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S CaillardUNKNOWN French PTLD Working Group
Jun 7, 2007·World Journal of Gastroenterology : WJG·Jean-Claude TrinchetMichel Beaugrand
Aug 19, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Norah A Terrault, Deborah B Adey
May 17, 2008·Transplant International : Official Journal of the European Society for Organ Transplantation·Juan TorresJose María Morales
Jul 30, 2008·Journal of Hepatology·Paul Martin, Fabrizio Fabrizi
Apr 18, 2009·Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie·C H DaleP J Marotta
Nov 7, 2013·American Journal of Nephrology·David A GoodkinMichel Jadoul
Jan 23, 2014·Journal of Hepatology·Seema Baid-AgrawalThomas Berg
Apr 11, 2014·Journal of Viral Hepatitis·F FabriziP Messa
Aug 6, 2014·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S Baid-AgrawalM Muche
Apr 1, 2015·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Julio A GutierrezAdam Peyton
Nov 21, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·N KamarL Alric
Nov 26, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·D SawinskiR D Bloom
Sep 27, 2016·Journal of Hepatology·UNKNOWN European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu
Apr 14, 2017·The Lancet. Gastroenterology & Hepatology·UNKNOWN Polaris Observatory HCV Collaborators
May 16, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Varun SaxenaK Rajender Reddy
Jan 23, 2018·Transplant International : Official Journal of the European Society for Organ Transplantation·Mario Fernández-RuizAmado Andrés
Feb 11, 2018·Liver International : Official Journal of the International Association for the Study of the Liver·Bruno RocheDidier Samuel
Feb 27, 2018·Transplant International : Official Journal of the European Society for Organ Transplantation·Ziad Zaky, Joshua J Augustine
Jul 10, 2018·Seminars in Liver Disease·Jeffrey V LazarusMassimo Colombo
Sep 25, 2018·BioMed Research International·Massimo SabbatiniFilomena Morisco
Nov 21, 2018·Nature Reviews. Nephrology·Stanislas PolMichel Jadoul
Dec 24, 2018·Transplant International : Official Journal of the European Society for Organ Transplantation·Mohamed GendiaPiergiorgio Messa
Jan 17, 2019·The Lancet. Gastroenterology & Hepatology·Graham S CookeUNKNOWN Lancet Gastroenterology & Hepatology Commissioners

❮ Previous
Next ❯

Citations

Mar 9, 2021·Annals of Hepatology·Fabrizio FabriziUNKNOWN Latin American Liver Research, Educational and Awareness Network (LALREAN)
May 4, 2021·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Tsung-Hui HuUNKNOWN Changhua Hepatitis C Elimination Task Force

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Related Papers

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology
Z W ChenH Ren
Transplant Infectious Disease : an Official Journal of the Transplantation Society
Marlina MansourJanice Kerr
Journal of Ayub Medical College, Abbottabad : JAMC
Muhammad UmarMuhammad Osama
© 2021 Meta ULC. All rights reserved