Elimination and phase II metabolism of ethanol in camels after intravenous administration

The Veterinary Journal
Ibrahim A WasfiB A Agha

Abstract

Ethanol elimination was studied in camels (n=8) after a single bolus intravenous dose of 0.1g/kg bodyweight (BW). Blood samples were then collected at set intervals. Ethanol and ethyl glucuronide (EtG) in blood were analysed by validated static headspace gas chromatography-mass spectrometry and liquid chromatography-mass spectrometry (LC-MS) methods, respectively. Blood-ethanol concentration-time profiles were plotted for each camel and these were evaluated. A simple linear regression model was fitted to the selected data points and the slope of the fitted line was used to estimate the elimination rate, the distribution factor and turnover rate, which were 5.15 mg/dL blood/h, 0.55 L/kg and 0.028 g/h/kg, respectively. Blood EtG concentration-time profiles were also plotted for each camel. The elimination half-life of EtG, estimated by linear regression (using the values obtained after ethanol was completely eliminated) was 2.18 h. The theoretical initial blood concentration of EtG (C(0)), obtained by extrapolation to time zero was 23.4 μg/dL. The results will be useful in monitoring alcohol doping in camels using either parent drug or metabolite.

References

Nov 1, 1987·Clinical Pharmacokinetics·N H Holford
Jan 3, 1997·Clinica Chimica Acta; International Journal of Clinical Chemistry·C S Lieber
Jan 16, 1999·Biochemical Pharmacology·H MatsumotoY Fukui
Apr 9, 1999·Alcoholism, Clinical and Experimental Research·D CrippensR A Gonzales
Jun 11, 2002·Journal of Analytical Toxicology·Helen DahlAnders Helander
Dec 13, 2003·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Ibrahim A WasfiNawal Abdulla Al Katheeri
Apr 24, 2004·Clinical Chemistry·Anders Helander, Olof Beck
Jul 30, 2004·The Biochemical Journal·Heiko Schneider, Hansruedi Glatt
Aug 3, 2005·The Veterinary Journal·N A Al KatheeriC Nebbia
Sep 6, 2005·Forensic Science International : Synergy·Robert S Foti, Michael B Fisher
Feb 20, 2007·Forensic Science International : Synergy·Gudrun HøisethJørg Mørland
Nov 2, 2007·Rapid Communications in Mass Spectrometry : RCM·Youwen YouJinwen Chen
Apr 28, 2009·Forensic Science International : Synergy·Alan Wayne Jones, Anita Holmgren

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Citations

Dec 19, 2018·Journal of Analytical Toxicology·Fernando X MoreiraPaula G de Pinho
Jan 14, 2021·Drug Testing and Analysis·Fernando MoreiraMaria de Lourdes Bastos

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