Elimination of alkaline phosphatases from circulation by the galactose receptor. Different isoforms are cleared at various rates

Clinica Chimica Acta; International Journal of Clinical Chemistry
E BlomN E Huseby

Abstract

Three isoforms of human alkaline phosphatase (liver, bone and placental ALP) were purified and their elimination studied after intravenous injection in rats. The rates of elimination were significantly inhibited by prior injection of asialofetuin, indicating that the uptake was mediated by the galactose receptor in liver. Their relative clearance rates differed, being rapid for the bone ALP, significantly slower for the liver isoform and very slow for the placental ALP. The bone ALP showed a rapid initial clearance, apparently related to its large glycan heterogeneity and to the presence of molecules with a low sialic acid content. When isolated from serum the liver and bone ALP isoforms showed clearance rates differing slightly from those of the organ derived forms. We conclude that differences in carbohydrate structure and amount of sialic acid of the three isoforms result in various clearance rates. These differences will also affect their serum concentrations as well as the composition and heterogeneity of the individual isoforms in serum.

References

Dec 1, 1978·The American Journal of Digestive Diseases·D B McGill
Jul 8, 1991·Biochimica Et Biophysica Acta·F RaymondD Moss
Feb 28, 1989·Clinica Chimica Acta; International Journal of Clinical Chemistry·M MiuraT Komoda
Feb 15, 1988·Clinica Chimica Acta; International Journal of Clinical Chemistry·K TakataK Adachi
Oct 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·M J WeissH Harris
Jul 1, 1986·Annals of Clinical Biochemistry·R W Wulkan, B Leijnse
Jan 1, 1982·Annual Review of Biochemistry·G Ashwell, J Harford
Jan 1, 1993·Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum·N E Huseby, O C Ingebretsen
Jul 1, 1993·Annals of Clinical Biochemistry·C P Price
Jan 1, 1993·Sub-cellular Biochemistry·P H Weigel
May 3, 2005·Nucleic Acids Research·Dan SuVadim N Gladyshev

❮ Previous
Next ❯

Citations

Dec 18, 2004·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Riitta TähteläM J Välimäki
Mar 31, 2005·Biochemical and Biophysical Research Communications·Azin Nowrouzi, Razieh Yazdanparast
Oct 9, 2002·Clinica Chimica Acta; International Journal of Clinical Chemistry·Per MagnussonJohn R Farley
Feb 19, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·X LiN E Huseby
Sep 17, 2002·Kidney International. Supplement·Ram GokalSalim Mujais
Aug 1, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D AlvaroG Alpini
Feb 23, 2008·Proceedings of the National Academy of Sciences of the United States of America·Ross F GoldbergRichard A Hodin
Oct 10, 2012·The Journal of Infectious Diseases·Ronald B MossRoy T Steigbigel
May 17, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jeffrey L LarsonFang Fang
Sep 24, 2015·Antiviral Research·Jonathan M ZenilmanJ McLeod Griffiss
Sep 2, 2015·International Journal of Pharmaceutics·Esther PetersPeter Pickkers
Jan 22, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Raoul Poupon
Jan 15, 2013·Bone·Cecilia Halling LinderPer Magnusson
Oct 28, 2008·Expert Opinion on Drug Metabolism & Toxicology·Darshika Chhabra, Kevin Nash
Feb 24, 2010·Scandinavian Journal of Clinical and Laboratory Investigation·Per MagnussonChristopher A Sharp
Aug 15, 2000·American Journal of Obstetrics and Gynecology·V VongthavaravatR S Koff
Dec 17, 2014·Chemico-biological Interactions·Adrianne F PikeRuud Brands
Jun 29, 2016·Hemodialysis International·Lenar YessayanJerry Yee
Oct 31, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Marsha WolfsonUNKNOWN Icodextrin Study Group
Jun 23, 2009·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Handan CelikErdal Malatyalýodlu
Oct 15, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Annemarie TuinKlaas Poelstra
Sep 19, 2017·Current Opinion in Lipidology·Marjolein A W van den BoogertAdriaan G Holleboom

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.