Jan 1, 1976

Elimination of allogeneic inhibition of hematopoietic stem cells by treatment of the recipient mice with cyclophosphane

Biulleten' eksperimental'noĭ biologii i meditsiny
I N Golovistikov

Abstract

The experiments demonstrated that pretreatment of lethally irradiated recipient (CBA X C57BL/6) F1hybrid mice with cyclophosphamide (200 mg/kg of body weight) on day before the bone marrow transplantation (4 hours after the irradiation) suppressed the allogeneic inhibition of hematopoietic stem cells to 24% (while the inhibition in the untreated animals was 92.5%). It is suggested that cyclophosphamide acted on the recipient's radioresistant lymphoid cells effecting the allogeneic inhibition of stem cells.

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Mentioned in this Paper

Cyclophosphamide
C57BL/6 Mouse
Bone Marrow
Lymphoid Cells
Weighing Patient
Graft Rejection
Metabolic Inhibition
Hemopoietic Stem Cell Transplant
Transplantation, Homologous
Transplantation Aspects

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