Elimination of beta-hexachlorocyclohexane in occupationally exposed persons

Journal of Toxicology and Environmental Health
D JungO Päpke

Abstract

The elimination of beta-hexachlorocyclohexane (beta-HCH) in humans was investigated in a group of 40 former workers of a lindane-producing plant by analyzing at least 2 blood specimens (3 specimens in 3 workers) from different time points. Assuming a first-order kinetic model for excretion, the median half-life of beta-HCH is 7.2 yr calculated by concentrations in whole blood and 7.6 yr calculated by concentrations in extractable lipids. In univariate analyses an influence of age, percent body fat, and liver disease (additionally in whole blood an influence of contents of extractable lipids) on clearance was observed. All factors show a positive correlation with half-life. According to a multiple regression model, influence of percent body fat calculated according to Deurenberg et al. (1991) is an important covariate in the description of the variations of the clearance rate (calculated on the basis of extractable lipids) of beta-HCH. The data support the assumption of first-order kinetics.

References

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Mar 1, 1996·Journal of Toxicology and Environmental Health·D Flesch-JanysO Päpke

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Citations

Dec 15, 2010·International Journal of Obesity : Journal of the International Association for the Study of Obesity·F HamanM A Robidoux
Sep 17, 2004·Journal of Toxicology and Environmental Health. Part a·Judy AkkinaAnnette Bachand
Jul 23, 2013·Environmental Health : a Global Access Science Source·Daniela PortaFrancesco Forastiere
Aug 21, 2013·Environmental Health Perspectives·Thuy LamRuss Hauser
Jan 20, 2020·Neurotoxicity Research·Jolene KokrokoBrenda Eskenazi
Feb 10, 2021·International Journal of Environmental Research and Public Health·Saira AmirAristidis Tsatsakis

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