Elimination of donor-specific alloreactivity prevents cytomegalovirus-accelerated chronic rejection in rat small bowel and heart transplants

Transplantation
Susan L OrloffCynthia R Wagner

Abstract

The primary cause for late failure of vascularized allografts is chronic rejection (CR) characterized by transplant vascular sclerosis (TVS). Cytomegalovirus (CMV) infection accelerates TVS and CR by unclear mechanisms involving direct effects of CMV, indirect effects of the recipient's immune response to CMV, or interactions between CMV and the recipient's alloreactivity. This study examined the role of CMV and the alloreactive response in the development of TVS using bone marrow chimerism (BMC) in rat small bowel (SB) and heart transplantation models. Fisher 344 (F344) rat heart or SB grafts were transplanted into F344/Lewis bone marrow chimera. F344 heart or SB grafts transplanted into Lewis recipients (low-dose cyclosporine) were positive controls for the development of TVS. Lewis heart or SB grafts transplanted into Lewis recipients (+/-cyclosporine) were transplantation controls. The effect of rat CMV (RCMV) (5x105 plaque-forming units) on TVS (neointimal index, NI) and graft survival was studied in these groups. RCMV infection was assessed by serologic analysis and quantitative polymerase chain reaction techniques (TaqMan). RCMV infection accelerated the time to graft CR (SB 70-38 days; hearts 90-45 days) and increased t...Continue Reading

References

Apr 30, 1992·The New England Journal of Medicine·T C MeriganR M Ratkovec
May 11, 1992·Transplantation·D H AdamsM J Karnovsky
Sep 1, 1991·American Journal of Respiratory Cell and Molecular Biology·L J GeistG W Hunninghake
Jun 23, 1989·JAMA : the Journal of the American Medical Association·M T GrattanN E Shumway
Jan 1, 1985·Intervirology·C A BruggemanC P van Boven
Nov 1, 1970·Proceedings of the Society for Experimental Biology and Medicine·B B Wentworth, L French
Dec 1, 1983·Antiviral Research·C A BruggemanC P van Boven
Dec 1, 1995·Journal of Virology·H ZhuT Shenk
Feb 1, 1994·The Journal of Clinical Investigation·L J GeistG W Hunninghake
Jan 1, 1996·Intervirology·R C VossenC A Bruggeman
Apr 15, 1997·Transplantation·A T ArmstrongC G Orosz
Feb 1, 1997·Transplantation Proceedings·T MarteliusI Lautenschlager
Jun 1, 1997·American Journal of Respiratory and Critical Care Medicine·P K KoskinenK B Lemström
Sep 1, 1997·Journal of Virology·S MichelsonM P Landini
Nov 22, 1997·Current Opinion in Immunology·B Nikolic, M Sykes
Sep 15, 1999·Proceedings of the National Academy of Sciences of the United States of America·N SaederupE S Mocarski
Oct 26, 1999·European Journal of Pediatric Surgery : Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Für Kinderchirurgie·J S Thompson
Mar 4, 2000·Proceedings of the National Academy of Sciences of the United States of America·S V KotenkoS Pestka
Jul 25, 2000·Journal of Virology·C VinkC A Bruggeman
Aug 5, 2000·Virchows Archiv : an International Journal of Pathology· Pampou SYuM E DeBakey

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Citations

Feb 19, 2013·The Journal of Infectious Diseases·Masako Shimamura
Jul 5, 2007·Current Opinion in Infectious Diseases·Luciano Potena, Hannah A Valantine
Aug 24, 2012·Journal of Virology·Jennifer VomaskeDaniel N Streblow
May 2, 2008·Journal of Virology·Jerome DumortierJay A Nelson
Oct 29, 2010·Journal of Virology·Christine MeyerDaniel N Streblow
Nov 1, 2011·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Rutger M van ReeStephan J L Bakker
Aug 11, 2010·Expert Review of Anti-infective Therapy·Tomás Reischig
Sep 28, 2010·Virus Research·Patrizia CaposioDaniel N Streblow
Feb 15, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Daniel N StreblowSusan L Orloff
May 25, 2005·Transplant International : Official Journal of the European Society for Organ Transplantation·Jan-Luuk HillebrandsJan Rozing
Jul 28, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A PascherP Reinke
Dec 21, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·D N StreblowS L Orloff
Nov 4, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·C H CookC G Orosz
Jan 5, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S L OrloffD N Streblow
Jun 1, 2011·Transplant International : Official Journal of the European Society for Organ Transplantation·Ji-Qiang ZhaoDe Qun Ni
Mar 1, 2006·Transplantation Proceedings·M BoratyńskaM Klinger
Mar 15, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·D N StreblowS L Orloff
Apr 8, 2009·Virology·Carmen C Baca JonesDaniel N Streblow
Dec 24, 2010·Cell Transplantation·M J SmeltP de Vos
Apr 24, 2004·The Journal of General Virology·L M SmithG R Shellam
Nov 19, 2020·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Nicole N HaeseDaniel N Streblow
Jan 7, 2021·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Iris K A JonesDaniel N Streblow

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