PMID: 3770277Sep 1, 1986Paper

Elimination of germ cells during differentiation of the human ovary: an electron microscopic study

European Journal of Obstetrics, Gynecology, and Reproductive Biology
P M Motta, S Makabe

Abstract

Observations by scanning and transmission electron microscopy during ovarian development (from 7 wk until term of gestation) showed numerous germ cells within the superficial epithelial layer covering the ovary. In early stages of differentiation (between 7 and 11 wk), germ cells appeared to be actively migrating to the surface of the ovary by ameboid-like movements. Later, the transfer of the germ cells to the surface epithelium was also occurring passively, as a consequence of an intense proliferation of germ and somatic cells - arranged in clusters and cords - migrating towards the most superficial areas of the ovary. The present evidence suggests that a number of primordial germ cells - as well as oogonia and oocytes - which lie in the superficial epithelium can leave the ovary and ultimately rest freely upon its surface. Elimination of germ cells during differentiation of the ovary in humans was always paralleled by necrosis of oogonia and oocytes and atretic alteration of primitive follicles. The significance of these processes is discussed in relation to the reduction of the pool of oocytes at birth.

References

Jun 1, 1975·The American Journal of Anatomy·P Motta, J Van Blerkom
Jul 29, 1975·Archiv für Gynäkologie·F Bonilla-MusolesJ Torres
Sep 1, 1969·Acta Endocrinologica·H Peters
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Jan 1, 1947·Journal of Gerontology·R L HERDENER

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Citations

Feb 3, 1998·European Journal of Obstetrics, Gynecology, and Reproductive Biology·P M MottaS Makabe
Apr 12, 2001·Clinical Genetics·H Ostrer
Jul 9, 2009·Molecular Human Reproduction·G M HartshorneF Ghafari
Apr 30, 2004·Reproductive Biology and Endocrinology : RB&E·Antonin BukovskyNirmala B Upadhyaya
May 6, 2005·Reproductive Biology and Endocrinology : RB&E·Antonin BukovskyMichael R Caudle
Feb 15, 2013·PloS One·Katja HummitzschRaymond J Rodgers
Jul 4, 2006·Reproduction : the Official Journal of the Society for the Study of Fertility·J B KerrJ K Findlay
Jun 5, 2012·Fertility and Sterility·Yohei HayashiShinya Yamanaka
Apr 30, 2008·Annals of the New York Academy of Sciences·Ozgur Oktem, Kutluk Oktay
Mar 24, 2009·Birth Defects Research. Part C, Embryo Today : Reviews·Ozgur Oktem, Kutluk Oktay
Aug 26, 2006·Developmental Biology·Sarah K Bristol-GouldTeresa K Woodruff
Oct 17, 2016·Molecular and Cellular Endocrinology·Alisha M TrumanDori C Woods
May 17, 2006·Microscopy Research and Technique·Antonin Bukovsky
Jan 4, 2007·The Journal of Pathology·O DjahanbakhchA Zosmer
Feb 28, 2019·Cellular and Molecular Life Sciences : CMLS·Wei GeWei Shen
Dec 30, 2014·Endocrine Reviews·Katja HummitzschRaymond J Rodgers

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