Elimination of lymphatic filariasis in Southeast Asia

Advances in Parasitology
Mohammad SudomoRobert Bergquist

Abstract

Approximately 15 million people with lymphatic filariasis (LF) live in Southeast Asia. Wuchereria bancrofti (transmitted by the Mansonia and Anopheles vectors), Brugia malayi and Brugia timori (both transmitted by Culex quinquefasciatus) are the filarial species in this region. The endemic countries are: Cambodia, Lao People's Democratic Republic, the Philippines, Indonesia, Thailand and Timor-Leste, which have all agreed to eliminate transmission of the disease by 2020. The public health interventions with respect to LF are based on the 1997 World Health Assembly resolution (WHA 50.29) which recommends elimination of the disease through mass drug administration (MDA) using diethylcarbamazine (DEC) and albendazole. The drugs are generally donated and as governments contribute 60-90% of the operational costs, MDA is deemed to be comparatively inexpensive for local administrations in relation to other public health programmes. So far, elimination has been accomplished only in the People's Republic of China (P.R. China) and this achievement is therefore described here in some detail. Resurgences have occurred but they have been successfully dealt with. Historically, the endemic areas in P.R. China covered 16,514 townships (or urba...Continue Reading

Citations

Dec 5, 2012·PLoS Neglected Tropical Diseases·Peter J Hotez
Oct 3, 2013·PLoS Neglected Tropical Diseases·Peter HotezXiao-Nong Zhou
Mar 4, 2014·PLoS Neglected Tropical Diseases·Melody TanPeter J Hotez
Nov 26, 2011·Current Medical Research and Opinion·Roberto CañeteM R C G Novaes
Jul 16, 2013·Infectious Diseases of Poverty·Xiao-Nong ZhouMarcel Tanner
Oct 12, 2014·Parasites & Vectors·Jorge CanoSimon J Brooker
Aug 2, 2011·Asian Pacific Journal of Tropical Medicine·Anish ChandyAshish Manigauha
Jan 18, 2018·Parasites & Vectors·Hong-Mei LiXiao-Nong Zhou
Jul 27, 2017·Tropical Medicine and Infectious Disease·Benjamin F R DicksonWilliam J McBride
Aug 17, 2020·Vector Borne and Zoonotic Diseases·Xiaodan HuangMaoqing Gong

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