Elimination of lymphatic filariasis in the Gambia

PLoS Neglected Tropical Diseases
Maria P RebolloMoses J Bockarie

Abstract

The prevalence of Wuchereria bancrofti, which causes lymphatic filariasis (LF) in The Gambia was among the highest in Africa in the 1950s. However, surveys conducted in 1975 and 1976 revealed a dramatic decline in LF endemicity in the absence of mass drug administration (MDA). The decline in prevalence was partly attributed to a significant reduction in mosquito density through the widespread use of insecticidal nets. Based on findings elsewhere that vector control alone can interrupt LF, we asked the question in 2013 whether the rapid scale up in the use of insecticidal nets in The Gambia had interrupted LF transmission. We present here the results of three independently designed filariasis surveys conducted over a period of 17 years (1997-2013), and involving over 6000 subjects in 21 districts across all administrative divisions in The Gambia. An immunochromatographic (ICT) test was used to detect W. bancrofti antigen during all three surveys. In 2001, tests performed on stored samples collected between 1997 and 2000, in three divisions, failed to show positive individuals from two divisions that were previously highly endemic for LF, suggesting a decline towards extinction in some areas. Results of the second survey conducte...Continue Reading

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Citations

Nov 23, 2017·The American Journal of Tropical Medicine and Hygiene·Kimberly Y WonMaria Rebollo
Jan 17, 2020·PLoS Neglected Tropical Diseases·Anne L WilsonSteve W Lindsay
Feb 28, 2016·Archives of Disease in Childhood·Meagan A BarryKathryn M Jones
Sep 20, 2015·Transactions of the Royal Society of Tropical Medicine and Hygiene·Irene Offei OwusuJohn O Gyapong
Mar 13, 2016·Parasitology Research·I P SunishN Arunachalam
Jan 30, 2016·Transactions of the Royal Society of Tropical Medicine and Hygiene·Patricia N Okorie, Dziedzom K de Souza
Jun 6, 2018·Parasites & Vectors·Joseph B KoromaYaobi Zhang
Jul 9, 2021·Royal Society Open Science·Pamela Kim N SalongaVicente Y Belizario
Apr 28, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·E L DavisT D Hollingsworth

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Methods Mentioned

BETA
MDA

Software Mentioned

Survey Sample Builder ( SSB )

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