Elimination of nadolol by patients with renal impairment

British Journal of Clinical Pharmacology
J HerreraD L Griffith

Abstract

1 Nadolol excretion was studied in 24 patients with chronic renal failure. 2 The amount of nadolol excreted during the 120-h period after receiving the drug ranged from less than 1% in functionally anephric, patients up to 11.5% in patients with average creatinine clearance of 57.9 +/- 3.6 ml/min/1.73 m2. 3 Renal clearance of nadolol was found to correlate with creatinine clearance; nadolol elimination is retarded in patients with renal failure. 4 Nadolol serum half-life is prolonged in proportion to the remaining renal function. Therefore, dosage intervals in renal patients receiving nadolol should be adjusted to creatinine clearance. 5 Haemodialysis effectively reduced serum concentration of the drug; it may therefore be a useful therapy for drug intoxication.

References

May 1, 1977·Journal of Clinical Pharmacology·J DreyfussD A Willard
Aug 1, 1977·Journal of Pharmaceutical Sciences·E Ivashkiv
Jun 1, 1976·Clinical Pharmacology and Therapeutics·C P Craig, S I Rifkin
Jul 1, 1977·Clinical Pharmacology and Therapeutics·B BeermannB Lindström
Aug 17, 1977·European Journal of Clinical Pharmacology·F Andreasen, E Mikkelsen

Citations

Jul 1, 1984·Canadian Anaesthetists' Society Journal·D C Chung, M J Laschuk
Sep 17, 1981·The New England Journal of Medicine·W H Frishman
Nov 1, 1980·Kidney International·M A Weber, J I Drayer
Nov 1, 1984·The American Journal of Emergency Medicine·A Heath
Oct 1, 1984·American Heart Journal·R S MichaelsN W Levin

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