PMID: 39993Aug 1, 1979

Elimination of prostacyclin (PGI2) and 6-oxo-PGF1 alpha in anaesthetized dogs

The Journal of Pharmacy and Pharmacology
J A SalmonJ R Vane

Abstract

The plasma concentration of 6-oxo-PGF1 alpha was measured by radioimmunoassay after constant rate infusion of 6-oxo-PGF1 alpha or prostacyclin (PGI2) into anaesthetized dogs. A steady-state plasma concentration was rapidly attained with both compounds. After termination of the infusions, the concentration of 6-oxo-PGF1 alpha declined according to a bi-exponential process. The steady-state plasma concentrations of 6-oxo-PGF1 alpha obtained after infusion of 6-oxo-PGF1 alpha and PGI2 were approximately 10 times higher than the corresponding steady-state level of PGF2 alpha measured after infusion of PGF2 alph into the same dogs. The data presented suggest that PGI2 and 6-oxo-PGF1 alpha are eliminated more slowly than PGF2 alpha, probably because they are not taken up and metabolized in the lungs as rapidly as PGF2 alpha.

References

Nov 1, 1985·Naunyn-Schmiedeberg's Archives of Pharmacology·V B FiedlerR Grützmann
Mar 1, 1987·Prostaglandins·T DashmanH E Gallo-Torres
Aug 1, 1991·Prostaglandins, Leukotrienes, and Essential Fatty Acids·F A PeetersA G Herman
Oct 7, 2004·Journal of Applied Physiology·Jennifer M LockwoodJohn R Halliwill
Nov 1, 1983·The Journal of Pharmacy and Pharmacology·U Förstermann, B Neufang
Sep 1, 1981·Archives internationales de physiologie et de biochimie·J DamasG Remacle-Volon

Related Concepts

Metabolic Process, Cellular
Lung
Flolan
Epoprostenol
Prostaglandins
Radioimmunoassay
Half-Life
Prostaglandins F
6-Ketoprostaglandin F1 alpha
Canis familiaris

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