Elimination of Schistosoma mansoni in infected mice by slow release of artemisone

International Journal for Parasitology. Drugs and Drug Resistance
Daniel GoldJacob Golenser

Abstract

The current treatment of schistosomiasis is based on the anti-helminthic drug praziquantel (PZQ). PZQ affects only the adult stages of schistosomes. In addition, resistance to PZQ is emerging. We suggest a drug, which could serve as a potential alternative or complement to PZQ, and as a means of treating infections at earlier, pre-granuloma stage. Derivatives of the peroxidic antimalarial drug artemisinin have been indicated as alternatives, because both plasmodia and schistosomes are blood-feeding parasites. The mechanism of action of artemisinins is related to oxidative effects of the artemisinins on intracellular reductants leading to formation of cytotoxic reactive oxygen species. We used artemisone, which has improved pharmacokinetics and anti-plasmodial activity, and reduced toxicity compared to other artemisinins in clinical use against malaria. We infected adult mice by subcutaneous injection of S. mansoni cercariae (about 200) and treated them at various times post infection by the following methods: i. artemisone suspension administered by gavage (400-450 mg/kg); ii. subcutaneous injection of a gel containing a known concentration of artemisone (115-120 mg/kg); iii. subcutaneous insertion of the drug incorporated in a...Continue Reading

Citations

Sep 14, 2018·ChemMedChem·Patrick MäderMartin Schlitzer
Feb 19, 2020·Phytotherapy Research : PTR·Muhammad Torequl IslamJavad Sharifi-Rad
Aug 19, 2017·Biomacromolecules·Gaigai DuanAndreas Greiner

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