PMID: 6968337Oct 1, 1980Paper

Elimination of syngeneic sarcomas in rats by a subset of T lymphocytes

The Journal of Experimental Medicine
E Fernandez-CruzJ D Feldman

Abstract

Established subcutaneous Moloney sarcomas (MST-1) of large size and long duration were eliminated from syngeneic rats by intravenous infusion of varying numbers of specific syngeneic effector T lymphocytes. Spleen cells from BN rats in which tumor had regressed were cultured in an in vitro mixed lymphocyte tumor cell culture (MLTC) to augment cytotoxicity of effector cells. In the MLTC a T cell subset was expanded in response to MST-1 antigens and transformed into blast elements. With these changes, there was an increase in the W3/25 antigen on the T cell surface, a decrease of W3/13 antigen, and an increase in the number of T cells with Ia antigens. The subset associated with elimination of established tumors was a blast T cell W3/25+, W3/13+, as detected by monoclonal antibodies to rat T antigens. The W3/25+ subset was poorly cytotoxic in vitro for MST-1 and apparently functioned in vivo as an amplifier or helper cell in the tumor-bearing host. The W3/25- population was a melange of cells that included (W3/13+, W3/25-) T cells, null cells, Ig+ cells, and macrophages, and was associated with enhancement of tumor in vivo, suggesting the presence of suppressor cells.

References

Feb 15, 1978·International Journal of Cancer. Journal International Du Cancer·D L PutmanM Kende
Aug 15, 1975·International Journal of Cancer. Journal International Du Cancer·J W Blasecki, S S Tevethia
Aug 1, 1977·The Journal of Experimental Medicine·D H SachsJ K Lunney
Dec 1, 1979·The Journal of Experimental Medicine·E L ReinherzS F Schlossman
Feb 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·L L PerryM I Greene
Dec 1, 1979·The Journal of Experimental Medicine·J E SwierkoszJ W Kappler
Nov 1, 1978·The Journal of Experimental Medicine·R L EvansS F Schlossman
Oct 1, 1978·The Journal of Experimental Medicine·S GillisK A Smith
Dec 1, 1978·The Journal of Experimental Medicine·M J BerendtD P Kirstein
Feb 1, 1979·The Journal of Experimental Medicine·B A Woda, J D Feldman
Jan 1, 1976·Annals of the New York Academy of Sciences·A FeferM A Cheever
Jan 1, 1976·Annals of the New York Academy of Sciences·A J TrevesM Feldman
Jun 15, 1975·International Journal of Cancer. Journal International Du Cancer·M Small, N Trainin
Mar 15, 1976·International Journal of Cancer. Journal International Du Cancer·J BruceG R Shellam
Nov 15, 1974·International Journal of Cancer. Journal International Du Cancer·S B HowellL W Llaw
Nov 1, 1972·International Journal of Cancer. Journal International Du Cancer·H BorbergE J Beattie
Jan 15, 1971·International Journal of Cancer. Journal International Du Cancer·S VadlamudiA Goldin

❮ Previous
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Citations

Jan 1, 1982·Cancer Metastasis Reviews·V SchirrmacherL Beck
Jan 1, 1990·Cancer Immunology, Immunotherapy : CII·M KohlerR M Zinkernagel
Apr 1, 1993·Journal of Neuroimmunology·F P Holladay, G W Wood
Jan 1, 1987·Immunology Today·P M Allen
Dec 17, 1986·Biochimica Et Biophysica Acta·R A Robins
Mar 21, 2008·Nature Reviews. Cancer·Steven A RosenbergMark E Dudley
Oct 1, 1982·The Journal of Experimental Medicine·H D EngersG D Sorenson
Jan 1, 1991·The Journal of Experimental Medicine·S Jung, H J Schluesener
Jun 1, 2012·Clinical & Developmental Immunology·Ivetta DanyleskoArnon Nagler
Sep 19, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Chrystal M PaulosNicholas P Restifo
Mar 1, 2007·Blood·Ainhoa Perez-DiezPolly Matzinger
Jan 1, 1994·Journal of Neurosurgery·F P HolladayG W Wood
Mar 29, 2001·Proceedings of the National Academy of Sciences of the United States of America·T Matsutake, P K Srivastava
Jan 1, 1986·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·W H de JongE J Ruitenberg
Apr 4, 2015·Science·Steven A Rosenberg, Nicholas P Restifo
Feb 1, 1985·Immunology Today·R A Robins, R W Baldwin
Apr 1, 1985·Clinical Immunology and Immunopathology·C C ChanD BenEzra
Jan 15, 1986·International Journal of Cancer. Journal International Du Cancer·M Zöller
Jan 1, 1986·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·H Fujiwara, T Hamaoka
Aug 15, 1988·International Journal of Cancer. Journal International Du Cancer·G FossatiG Parmiani
Jul 15, 1988·International Journal of Cancer. Journal International Du Cancer·R BianchiM C Fioretti
Apr 15, 1983·International Journal of Cancer. Journal International Du Cancer·L RomaniM C Fioretti
Jan 1, 1983·Immunological Reviews·D W MasonM L Thomas
May 15, 1985·International Journal of Cancer. Journal International Du Cancer·L RomaniM C Fioretti
Jan 1, 1988·Japanese Journal of Cancer Research : Gann·T YoshiokaT Hamaoka
Nov 21, 2015·The Cancer Journal·Cassian YeeAaron J Schueneman
Jan 1, 1989·Critical Reviews in Oncology/hematology·P M SondelP Fisch

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