PMID: 9189739May 1, 1997Paper

Elimination of tritium-labelled hyaluronic acid from normal and osteoarthritic rabbit knee joints

European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies
K LindenhaynK Pohlenz

Abstract

The half-life of [3H]hyaluronic acid in rabbit knee joints was estimated using two methods: (i) by following the [3H]hyaluronan content of the synovial fluid after intra-articular injection and (ii) by following the 3H2O radioactivity of plasma after intra-articular injection of [3H]hyaluronan. For normal rabbits we obtained a half-life of 15.8 hours (method I) and 17.5 +/- 1.0 hours (mean +/- SEM, method II), respectively. The second method was used to estimate the kinetics of the hyaluronan elimination from normal, sham-operated, as well as from osteoarthritic rabbit knee joints (Colombo model of osteoarthritis). Four weeks after injury, during the developing phase of osteoarthritis, the half-life of hyaluronan rose significantly to 23.5 +/- 2.1 hours and returned to normal levels (17.4 +/- 2.7 hours) 12 weeks after the operation (osteoarthritis developed). At the stage of developed osteoarthritis, the clearance rates were considerably higher than in normal rabbits.

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Citations

Jan 12, 2007·Clinical Rheumatology·Rondinelle Ribeiro CastroFrancisco Airton Castro da Rocha
Dec 1, 2014·Rheumatology and Therapy·Thierry ConrozierMarguerite Rinaudo
Oct 11, 2015·Joint, Bone, Spine : Revue Du Rhumatisme·Thierry Conrozier
Jan 19, 2008·The Journal of Physiology·K R IngramJ R Levick

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