Elimination of vascular fibrointimal hyperplasia by somatostatin receptor 1,4-selective agonist

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
E AavikP Häyry

Abstract

The somatostatin analogs octreotide and lanreotide, selective to receptor subtypes 2 and 5, failed clinical efficacy for the prevention of restenosis after percutaneous transluminal angioplasty. These findings might have been the result of targeting a wrong subset of receptors. In rat arteries, subtypes 1 and 4 are expressed 3-4 times more prominently than 2 and 5, and subtype 1 is the nearly exclusive subtype in atherosclerotic human vessels. Here, we demonstrate that daily s.c. injections (50-500 microg/kg/d) of CH275 (DesAA1,2,5(D-W8,IAmp9)Somatostatine-14), selective to subtypes 1 and 4, dose-dependently inhibited intimal hyperplasia 14 days after rat carotid denudation injury (for intimal area P=0.0002 across the dose range). CH275 was more effective than somatostatin-14 (equal affinity to all five subtypes, P=0.03), or octreotide (selective to subtypes 2 and 5, P=0.098). When rats were given the peptides for 14 days with end-point at 28 days, CH275 still significantly inhibited intimal area expansion. Both CH275 and octreotide inhibited the outgrowth of cells from postinjury aortic tissue punch-explants and the distance migrated in vitro, but not cell replication, which indicated that the effects of somatostatin analogs w...Continue Reading

References

May 1, 1991·Journal of the American College of Cardiology·C F LunderganP W Ramwell
Jan 1, 1983·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·O H Iversen
May 1, 1984·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·J Grünwald, C C Haudenschild
Jan 1, 1995·Life Sciences·Y C PatelC B Srikant
Sep 15, 1995·Transplantation·D PlissonnierJ B Michel
Aug 1, 1993·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·P HäyryT Paavonen
Nov 21, 1997·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M MyllärniemiP Häyry
Feb 11, 1999·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·S KhareA Y Patel
May 18, 1999·Biochemical and Biophysical Research Communications·L ChenA H Tashjian
Jun 9, 1999·Proceedings of the National Academy of Sciences of the United States of America·S MäkeläP Häyry
Aug 6, 1999·Frontiers in Neuroendocrinology·Y C Patel
Dec 30, 1999·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·L M MyllärniemiP J Häyry
Jun 14, 2000·American Journal of Physiology. Heart and Circulatory Physiology·S B CurtisA M Buchan
Nov 9, 2000·European Journal of Endocrinology·C BrunsG Weckbecker
Jun 8, 2001·The Journal of Clinical Investigation·J L HillebrandsJ Rozing
Aug 30, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L H OttesenF Bendtsen

❮ Previous
Next ❯

Citations

Oct 24, 2007·Journal of Vascular Surgery·Seung-Kee MinAlexander W Clowes
Nov 5, 2004·The Journal of Pharmacy and Pharmacology·Peter BirkenhauerBruno Gander
Jan 2, 2007·Transplantation·Pekka Häyry
Feb 4, 2009·Toxicologic Pathology·Monique Y WellsPhilippe Picaut
Aug 31, 2004·The Journal of Pharmacology and Experimental Therapeutics·Mia EngströmSiegfried Wurster
Oct 22, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Einari AavikPekka Häyry

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.