PMID: 15329591Aug 27, 2004Paper

Elimination rate constant describing clearance of infused fluid from plasma is independent of large infusion volumes of 0.9% saline in sheep

Anesthesiology
Christer H SvensenDonald S Prough

Abstract

The purpose of this study was to determine the influence of varying large crystalloid infusion volumes, ranging from a volume that has been safely administered to volunteers to a volume that greatly exceeds a practical volume for studies in normovolemic humans, of rapidly infused 0.9% saline on the elimination rate constant in sheep. Six sheep underwent three randomly ordered, 20 min, intravenous infusions of 0.9% saline in volumes of 25 ml/kg, 50 ml/kg and 100 ml/kg. Repeated measurements of arterial plasma dilution were analyzed using the volume kinetic approach to determine the apparent volumes of the central (V1) and peripheral (V2) body fluid spaces, the elimination rate constant (kr) describing clearance from the central fluid space and the rate constant (kt) for the diffusion of fluid between the central and the peripheral fluid spaces. The latter constant was split in to two constants, one describing flow out from the central fluid space and one describing flow into the central fluid space. Urinary output was measured in all sheep. kr was comparable at each infused volume (38.3 +/- 4.5, 32.2 +/- 4.2, and 36.7 +/- 7.0 ml/min, respectively, in the 25 ml/kg, 50 ml/kg, and 100 ml/kg protocols). However, for the largest infu...Continue Reading

References

Oct 1, 1991·Acta Anaesthesiologica Scandinavica·R G Hahn
Nov 1, 1987·Acta Anaesthesiologica Scandinavica·P Cox
Jan 1, 1993·Physiological Reviews·K Aukland, R K Reed
Feb 1, 1997·British Journal of Anaesthesia·R G HahnL Ståhle
Jan 23, 1999·Anesthesiology·D Drobin, R G Hahn
Mar 20, 1999·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·C SvensénR G Hahn
Oct 24, 2002·British Journal of Anaesthesia·K HolteH Kehlet
Apr 17, 2003·British Journal of Anaesthesia·F Sjöstrand, R G Hahn

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Citations

Jul 25, 2007·Anesthesia and Analgesia·Kathrine HolteHenrik Kehlet
Jul 9, 2010·Anesthesiology·Robert G Hahn
Jul 12, 2016·The American Journal of Emergency Medicine·Claire RogerJean-Yves Lefrant
Jul 1, 2010·Korean journal of anesthesiology·Eun Ho LeeKyu Taek Choi
Mar 21, 2006·Current Opinion in Anaesthesiology·Barbara Kabon, Andrea Kurz
Oct 8, 2005·The International Journal of Artificial Organs·J V Di Carlo, S R Alexander
Dec 18, 2020·Frontiers in Veterinary Science·Xiu Ting YiewWilliam W Muir

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