Ellagic acid inhibits HIV-1 infection in vitro: Potential role as a novel microbicide

Oral Diseases
A PromsongW Nittayananta

Abstract

To investigate the in vitro effects of ellagic acid on HIV-1 replication. Anti-HIV-1 activity of ellagic acid was determined in vitro using X4-tropic HIV-1NPO3 and R5-tropic pBaL Env-recombinant virus. Anti-HIV-1NPO3 activity of ellagic acid was investigated at a multiplicity of infection (MOI) of 0.01. Anti-HIV-1 integrase and protease activities of ellagic acid were tested using in vitro integration and proteolytic cleavage assays. Ellagic acid, added either before or after HIV-1NPO3 exposure, suppressed replication of the virus in C8166 cells up to 34%. Ellagic acid showed an anti-integrase IC50 of 8.7 μM. No cytotoxicity of ellagic acid at concentrations ranging from 12.5 to 100 μM was observed. We conclude that ellagic acid can inhibit HIV-1 infection without cytotoxicity. Thus, it may be a new effective agent that has potential to be developed as a novel microbicide against HIV-1.

References

Nov 3, 2005·Bioorganic & Medicinal Chemistry·Sarot CheenprachaSupinya Tewtrakul
Jan 13, 2006·Journal of Ethnopharmacology·Supinya TewtrakulPranee Rattanasuwan
Mar 18, 2008·Journal of Ethnopharmacology·Rui-Rui WangYong-Tang Zheng
Sep 17, 2013·Pharmaceutical Biology·A SuedeeP Panichayupakaranant

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Citations

Apr 15, 2020·Antimicrobial Agents and Chemotherapy·Zachary J SandlerBryan C Mounce
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Alon Ben DavidAmram Torgeman

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