Elsholtzia ciliata (Thunb.) Hyl. Extracts from Different Plant Parts: Phenolic Composition, Antioxidant, and Anti-Inflammatory Activities

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Lauryna PudziuvelyteJurga Bernatoniene

Abstract

Polyphenols play an important role on the health-promoting properties of humans. Plants belonging to Lamiaceae family are known as rich source of phenolic compounds. The current work aimed to evaluate the phenolic compounds, antioxidant, and anti-inflammatory activity of Elsholtzia ciliata (Thunb.) Hyl. ethanolic extracts from leaf, stem, flower, and whole herb. Twelve compounds were identified in ethanolic extracts using high-performance liquid chromatography (HPLC). The HPLC analysis revealed that chlorogenic acid, rosmarinic acid, and rutin were predominant compounds in ethanolicic extracts. Using HPLC-ABTS (2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)) post-column assay, avicularin, chlorogenic, and rosmarinic acids were identified as the predominant radical scavengers in all ethanolic extracts. All tested preparations significantly reduced the level of secretion of proinflammatory cytokines TNF-α, IL-6, and prostaglandin E2 induced by lipopolysaccharide treatment in mouse peritoneal macrophage cell culture. Stem and flower extracts were most efficient in reducing cytokine release, but leaf extract demonstrated stronger effect on prostaglandin E2 secretion. This is the first study exploring antioxidant efficiency ...Continue Reading

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Citations

May 14, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lauryna PudziuvelyteJurga Bernatoniene
May 16, 2020·Antioxidants·Agnieszka Tajner-CzopekAnna Sokół-Łętowska
Dec 11, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Halina Maria Ekiert, Agnieszka Szopa

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