Elucidating fentanyls differentiation from morphines in chemical and biological samples with surface-enhanced Raman spectroscopy

Electrophoresis
Kai WangJianwei Xie

Abstract

Fentanyl and morphine are opioid drugs as well as new psychoactive substances. Even originally introduced as efficient anesthetic drugs to relieve moderate-to-severe pain in clinic, the overdose of new synthetic opioids is currently a serious public health problem in numerous countries worldwide. The entire category of fentanyls has been included in the regulatory list in several countries. There is a great and urgent demand to rapidly recognize fentanyls and morphines in various samples. Here, we report an on-site surface-enhanced Raman spectroscopic method to classify fentanyls from morphines by the Raman spectroscopic signature of the molecular scaffold structure, with an assistance of principle component analysis algorithm. Moreover, by simple but fine-tuning approach of inorganic salt-induced aggregation of gold nanoparticles substrate, we achieved a selective detection of 10 ng/mL fentanyl from 2000-fold of heroin, the most common coexisting substance in chemical samples. Good differentiation of 50 ng/mL fentanyl from 10 000-fold morphine as a main metabolite of heroin in urine samples was also possible after a feasible pretreatment by StageTip procedures. Depending on different structures, the detection sensitivity of fi...Continue Reading

References

Jul 1, 1980·Clinical Pharmacology and Therapeutics·D A McClain, C C Hug
Mar 29, 2006·Biochimica Et Biophysica Acta·S G Kazarian, K L A Chan
Oct 13, 2006·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Nadine F J Van Nimmen, Hendrik A F Veulemans
Apr 27, 2007·Analytical Chemistry·Wolfgang HaissDavid G Fernig
Aug 1, 2008·Current Clinical Pharmacology·Elisabeth J RookJos H Beijnen
Feb 7, 2012·The Journal of Physical Chemistry. C, Nanomaterials and Interfaces·Shin MuramotoDavid G Castner
Jul 31, 2012·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Sussan GhassabianMaree T Smith
May 16, 2015·The International Journal on Drug Policy·Jane MounteneyPaul Griffiths
Apr 23, 2016·Analytical Chemistry·Thalita Guedes SilvaThiago Regis Longo Cesar Paixão
Jul 30, 2016·Forensic Science International : Synergy·Vera CoopmanVincent Cirimele
Jun 6, 2017·Addictive Behaviors·Theodore J CiceroZachary A Kasper
Jan 26, 2018·Forensic Toxicology·Nektaria MisailidiSotiris Athanaselis
Apr 11, 2018·Drug Testing and Analysis·Marykathryn Tynon MoodyBarry K Logan
May 15, 2018·ACS Chemical Neuroscience·Andrea L DevereauxChristopher W Cunningham
Jun 13, 2018·ACS Chemical Neuroscience·S Mallory BurnsSusan L Mercer
Jul 31, 2018·Journal of Hazardous Materials·Adam J GushgariRolf U Halden
Sep 25, 2018·Analytical Chemistry·Abed HaddadJohn R Lombardi
Aug 4, 2019·International Journal of Offender Therapy and Comparative Criminology·Minqi Zhao

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Citations

Jan 26, 2021·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Siqingaowa HanWuliji Hasi
Sep 8, 2020·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Siqingaowa HanWuliji Hasi

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