Elucidating the higher-order structure of biopolymers by structural probing and mass spectrometry: MS3D.

Journal of Mass Spectrometry : JMS
Daniele Fabris, Eizadora T Yu

Abstract

Chemical probing represents a very versatile alternative for studying the structure and dynamics of substrates that are intractable by established high-resolution techniques. The implementation of MS-based strategies for the characterization of probing products has not only extended the range of applicability to virtually all types of biopolymers but has also paved the way for the introduction of new reagents that would not have been viable with traditional analytical platforms. As the availability of probing data is steadily increasing on the wings of the development of dedicated interpretation aids, powerful computational approaches have been explored to enable the effective utilization of such information to generate valid molecular models. This combination of factors has contributed to making the possibility of obtaining actual 3D structures by MS-based technologies (MS3D) a reality. Although approaches for achieving structure determination of unknown targets or assessing the dynamics of known structures may share similar reagents and development trajectories, they clearly involve distinctive experimental strategies, analytical concerns and interpretation paradigms. This Perspective offers a commentary on methods aimed at o...Continue Reading

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Aug 7, 2013·Journal of Structural and Functional Genomics·Eric D MerkleyJoshua N Adkins
Nov 1, 2011·Journal of the American Society for Mass Spectrometry·Michael GötzeAndrea Sinz
Feb 21, 2013·Journal of the American Society for Mass Spectrometry·Eric D MerkleyJoshua N Adkins
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May 23, 2014·Journal of the American Society for Mass Spectrometry·Matteo ScalabrinDaniele Fabris
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Oct 1, 2021·Chemical Reviews·Eric LargyValérie Gabelica

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