Elucidating the murine brain transcriptional network in a segregating mouse population to identify core functional modules for obesity and diabetes

Journal of Neurochemistry
Pek Yee LumEric E Schadt

Abstract

Complex biological systems are best modeled as highly modular, fluid systems exhibiting a plasticity that allows them to adapt to a vast array of changing conditions. Here we highlight several novel network-based approaches to elucidate genetic networks underlying complex traits. These integrative genomic approaches combine large-scale genotypic and gene expression results in segregating mouse populations to reconstruct reliable genetic networks underlying complex traits such as disease or drug response. We apply these novel approaches to one of the most extensive surveys of gene expression studies ever undertaken in whole brain in a segregating mouse population. More than 23,000 genes were monitored in whole brain samples from more than 300 mice derived from an F2 intercross population and genotyped at over 1200 SNP markers uniformly spread over the entire genome. We explore the topological properties of the brain transcriptional network and highlight different approaches to inferring causal associations among genes by integrating genotypic and expression data. We demonstrate the utility of these approaches by identifying and experimentally validating brain gene expression traits predicted to respond to a strong expression qua...Continue Reading

References

Oct 7, 1994·Science·M W KirschnerE O Teisberg
Apr 1, 1997·Molecular Endocrinology·L Pei, S Melmed
Sep 25, 1998·Critical Reviews in Biochemistry and Molecular Biology·A LükingU Schmidt
Oct 16, 1999·Science·A L Barabasi, R Albert
Dec 11, 1999·Nature·L H HartwellA W Murray
Aug 10, 2000·Cell·T R HughesS H Friend
Jun 22, 2001·Trends in Genetics : TIG·R C Jansen, J P Nap
Feb 2, 2002·Nature·Laura J van 't VeerStephen H Friend
Mar 30, 2002·Science·Rachel B BremLeonid Kruglyak
Aug 31, 2002·Science·E RavaszA L Barabási
Oct 26, 2002·Science·Tong Ihn LeeRichard A Young
Nov 5, 2002·Proceedings of the National Academy of Sciences of the United States of America·M L Wayne, L M McIntyre
Feb 8, 2003·Brain Research. Molecular Brain Research·Hirokazu TakahashiMasumi Abe
Mar 11, 2003·Proceedings of the National Academy of Sciences of the United States of America·Zhiyong WangShlomo Melmed
Mar 21, 2003·Nature·Eric E SchadtStephen H Friend
Jan 20, 2004·Molecular and Cellular Biology·Eiji SakashitaAkila Mayeda
Jan 22, 2004·Nature Reviews. Genetics·Albert-László Barabási, Zoltán N Oltvai
Apr 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·Peter J SaboJohn A Stamatoyannopoulos
Jul 23, 2004·Nature·Michael MorleyVivian G Cheung
Sep 2, 2004·Neuron·Russell N Van Gelder
Sep 17, 2004·Nature·Nicholas M LuscombeMark Gerstein
Nov 30, 2004·Science·Insuk LeeEdward M Marcotte
Apr 20, 2005·Genome Research·Sudheer DossAldons J Lusis
Apr 23, 2005·Science·Fred W TurekJoseph Bass
May 12, 2005·Clinical Biochemistry·Mohamed Abdelhaleem
May 24, 2005·Cell·Marc W Kirschner
May 28, 2005·Molecular Endocrinology·Vera ChesnokovaShlomo Melmed
Jun 4, 2005·The EMBO Journal·B Kate DredgeRobert B Darnell
Jun 18, 2005·Current Opinion in Neurobiology·Diane Lipscombe

❮ Previous
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Citations

Jul 27, 2007·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Solveig K Sieberts, Eric E Schadt
Mar 17, 2012·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Jason A Bubier, Elissa J Chesler
Mar 18, 2008·Nature·Yanqing ChenEric E Schadt
Oct 20, 2009·Human Molecular Genetics·Amy S LeonardsonEric E Schadt
Jul 7, 2009·Annual Review of Nutrition·Gianni Panagiotou, Jens Nielsen
May 20, 2009·The Journal of Clinical Investigation·Victor N UebeleJohn J Renger
Jun 6, 2013·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Maria J WorshamGeorge Divine
Jul 24, 2013·BMC Genomics·Eric NilssonMichael K Skinner
Feb 20, 2010·PLoS Computational Biology·Jun ZhuEric E Schadt
Dec 15, 2010·PLoS Computational Biology·Benjamin A Logsdon, Jason Mezey
Aug 29, 2006·PLoS Genetics·Anatole GhazalpourSteve Horvath
Dec 30, 2008·PloS One·Ian C GrieveJonathan Mangion
Jul 28, 2010·PloS One·Eric E NilssonMichael K Skinner
Nov 29, 2011·Pharmacogenomics·Andrew KasarskisEric Schadt
Jan 1, 2014·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Robert HitzemannShannon McWeeney
Dec 19, 2007·Radiation and Environmental Biophysics·Ludwig FeinendegenEberhard O Voit
Jan 18, 2013·Current Cardiovascular Risk Reports·Qingying MengXia Yang
Jun 26, 2013·Seminars in Immunology·Shuzhao LiBali Pulendran
Jul 19, 2012·Molecular Systems Biology·I-Ming WangChristopher Roberts
Dec 19, 2014·Frontiers in Pharmacology·Eric E SchadtKalpana M Merchant
Jun 18, 2016·The Laryngoscope·Lamont R JonesMaria J Worsham
Mar 25, 2008·Advances in Genetics·Jun ZhuEric E Schadt
Jul 13, 2006·Journal of Lipid Research·Karen Reue, Laurent Vergnes
Apr 18, 2013·Nature Communications·Il-Jin KimAllan Balmain
Sep 1, 2017·Journal of Cellular Biochemistry·Yu TangPing-Tai Cai
Oct 23, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Stephen M SchwartzSu-In Lee

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