Elucidating the protein cold-adaptation: Investigation of the parameters enhancing protein psychrophilicity

Journal of Theoretical Biology
Mina JahandidehNader Hodjati Firoozabadi

Abstract

To investigate the role of the critical parameters in adaptation of proteins to low temperatures, a comparative systematic analysis was performed. Several parameters were proposed to have contribution to cold adaptation of proteins. Among proposed parameters, total values of residual structure states, secondary structure states and oligomeric states were alike in both psychrophilic and mesophilic proteins. In addition, our results provided new quantitative information about the trends in the substitution preference of Ile, Phe, Tyr, Lys, Arg, His, Glu and Leu with most of amino acids and substitution avoidance of Gly, Thr and Ala with most of amino acids. These findings would help future efforts propose a strategy for designing psychrophilic proteins.

References

Jan 20, 1992·Journal of Molecular Biology·K C Chou
Dec 1, 1987·Protein Engineering·M Vihinen
Dec 10, 1997·Biochimica Et Biophysica Acta·C GerdayG Feller
Dec 23, 1998·Protein Engineering·A Karshikoff, R Ladenstein
Apr 25, 2000·Protein Engineering·S KumarR Nussinov
Feb 26, 2004·Protein Engineering·Giulio GianeseStefano Pascarella
Apr 22, 2004·The Journal of Biological Chemistry·Euiyoung Bae, George N Phillips
Apr 6, 2005·Journal of Chemical Information and Modeling·Kuo-Chen Chou, Yu-Dong Cai
Apr 7, 2005·International Journal of Biological Macromolecules·Seung Pil Pack, Young Je Yoo
Oct 19, 2006·Journal of Biotechnology·Guangya Zhang, Baishan Fang
Feb 6, 2007·Journal of Theoretical Biology·Samad JahandidehEbrahim Barzegari Asadabadi
Aug 3, 2007·Journal of Theoretical Biology·Samad JahandidehSomayyeh Hoseini

❮ Previous
Next ❯

Citations

Oct 31, 2012·International Journal of Molecular Sciences·Caroline Struvay, Georges Feller
Aug 2, 2015·Journal of Theoretical Biology·Soheila ShokrollahzadeSamad Jahandideh
Feb 1, 2011·Journal of Structural Biology·Matteo Tiberti, Elena Papaleo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.