Elucidation of a tripartite mechanism underlying the improvement in cardiac tolerance to ischemia by coenzyme Q10 pretreatment

The Journal of Thoracic and Cardiovascular Surgery
J A CrestanelloG J Whitman

Abstract

Coenzyme Q10, which is involved in mitochondrial adenosine triphosphate production, is also a powerful antioxidant. We hypothesize that coenzyme Q10 pretreatment protects myocardium from ischemia reperfusion injury both by its ability to increase aerobic energy production and by protecting creatine kinase from oxidative inactivation during reperfusion. Isolated hearts (six per group) from rats pretreated with either coenzyme Q10, 20 mg/kg intramuscularly and 10 mg/kg intraperitoneally (treatment) or vehicle only (control) 24 and 2 hours before the experiment were subjected to 15 minutes of equilibration, 25 minutes of ischemia, and 40 minutes of reperfusion. Developed pressure, contractility, compliance, myocardial oxygen consumption, and myocardial aerobic efficiency were measured. Phosphorus 31 nuclear magnetic resonance (31P-NMR) spectroscopy was used to determine adenosine triphosphate and phosphocreatine concentrations as a percentage of a methylene diphosphonic acid standard. Hearts were assayed for myocardial coenzyme Q10 and myocardial creatine kinase activity at end equilibration and at reperfusion. Treated hearts showed higher myocardial coenzyme Q10 levels (133 +/- 5 micrograms/gm ventricle versus 117 +/- 4 microgram...Continue Reading

References

Jun 1, 1992·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·R E Beyer
Jul 1, 1992·Hypertension·J I Goldhaber, J N Weiss
Dec 1, 1991·European Heart Journal·P A Poole-WilsonA J Williams
Oct 1, 1991·Cardiovascular Drugs and Therapy·E Braunwald
Oct 1, 1991·Circulation Research·Y OhgoshiH Suga
Jan 1, 1991·Journal of Molecular and Cellular Cardiology·W FlamengH Van Belle
Jul 1, 1990·Journal of Clinical Pharmacology·S Greenberg, W H Frishman
Sep 1, 1990·Circulation·R Bolli
Jan 1, 1990·The International Journal of Biochemistry·H SugawaraK Momose
Mar 1, 1990·Basic Research in Cardiology·E N DeanJ M Nicklas
Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·B FreiB N Ames
Jan 1, 1990·Free Radical Research Communications·G LenazG Parenti Castelli
Apr 1, 1989·Journal of Molecular and Cellular Cardiology·S B LasterW E Jacobus
Jan 1, 1987·Scandinavian Journal of Thoracic and Cardiovascular Surgery·O ReikeråsK Nordstrand
Jan 1, 1985·Annual Review of Biochemistry·S P Bessman, C L Carpenter
Nov 1, 1985·The Journal of Clinical Investigation·E Braunwald, R A Kloner
Jul 1, 1995·The Journal of Surgical Research·J A CrestanelloG J Whitman
Sep 1, 1994·The Annals of Thoracic Surgery·S F BollingX H Ning
Jan 1, 1994·Cardiovascular Research·H M PiperB Siegmund
Jan 1, 1993·The Clinical Investigator·F RengoN Ferrara
Jan 1, 1993·The Clinical Investigator·W V JudyK Folkers
Jan 1, 1993·The Clinical Investigator·F L CraneE E Sun
Jan 1, 1993·The Clinical Investigator·L Ernster, P Forsmark-Andrée

❮ Previous
Next ❯

Citations

Jan 1, 1997·Molecular Aspects of Medicine·G J WhitmanR Momeni
May 30, 2001·Advanced Drug Delivery Reviews·D MorinJ Tillement
Oct 13, 2000·Journal of the American College of Surgeons·T N RobinsonA H Harken
Apr 24, 2007·Biochemistry. Biokhimii︠a︡·E I KalenikovaO S Medvedev
Jul 22, 1998·Proceedings of the National Academy of Sciences of the United States of America·R T MatthewsM F Beal
Jul 30, 2009·Pharmacology & Therapeutics·Adarsh KumarVarun Mohan
May 15, 2015·Annual Review of Nutrition·Anita AyerRoland Stocker
Feb 14, 2002·The Journal of Surgical Research·Juan A CrestanelloGlenn J R Whitman
Jul 19, 2016·Pharmacological Reports : PR·Jerzy JankowskiAnna Jabłecka
May 28, 2005·Seminars in Cardiothoracic and Vascular Anesthesia·Mary Keith, Lee Errett
Jul 23, 1999·BioFactors·P H Langsjoen, A M Langsjoen
Feb 20, 2002·FEBS Letters·Hiroko MiyaderaKiyoshi Kita
May 9, 2007·Mitochondrion·Salvatore PepeFranklin L Rosenfeldt
Apr 14, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Gamil M AbdallahOsama M Abo-Salem

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.