Elucidation of penetration enhancement mechanism of Emu oil using FTIR microspectroscopy at EMIRA laboratory of SESAME synchrotron

Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Randa S H MansourIbraheem Yousef

Abstract

It has been proposed that Emu oil possesses skin permeation-enhancing effect. This study aimed to address its possible penetration enhancement mechanism(s) using IR microscopy, in accordance with LPP theory. The penetration of Emu oil through the layers of human skin was accomplished by monitoring oil-IR characteristic feature at 3006cm-1. The unsaturated components of Emu oil accumulated at about 270μm depth of skin surface. The interaction of Emu oil with lipid and protein constituents of SC was investigated in comparison with a commonly used enhancer, IPM. Inter-sample spectral differences were identified using PCA and linked with possible enhancement mechanisms. Emu oil treatment caused a change in the slope of the right contour of amide I band of the protein spectral range. This was also clear in the second derivative spectra where the emergence of a new shoulder at higher frequency was evident, suggesting disorganization of keratin α-helix structure. This effect could be a result of disruption of some hydrogen bonds in which amide CO and NH groups of keratin are involved. The low intensity of the emerged shoulder is also in agreement with formation of weaker hydrogen bonds. IPM did not affect the protein component. No con...Continue Reading

Citations

Nov 29, 2017·International Journal of Molecular Sciences·Marcelle Silva-AbreuAna Cristina Calpena
Feb 14, 2019·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Marc A OliverClara Barba
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Jul 11, 2020·Journal of Liposome Research·Usha SundralingamUma D Palanisamy
Jun 21, 2021·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Despina MoissidouGihan Kamel
Jul 20, 2021·Asian Journal of Pharmaceutical Sciences·Danping ZhangJianqing Gao
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Nov 30, 2021·Integrative Cancer Therapies·Stacy D'AndreCharles Loprinzi

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