Elucidation of the interactions of an anticancer ruthenium complex in clinical trials with biomolecules utilizing capillary electrophoresis hyphenated to inductively coupled plasma-mass spectrometry. Short communication

Chemistry & Biodiversity
Michael GroesslBernhard K Keppler

Abstract

The application of capillary electrophoresis (CE) combined with highly sensitive inductively-coupled-plasma mass spectrometric (ICP-MS) detection allows the interactions of metal complexes with biomolecules to be characterized. This technique has been used to provide new insights into the mode of action of the ruthenium-based anticancer drug candidate indazolium [trans-tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019). While the compound binds rapidly and efficiently to serum proteins, especially albumin, its reactivity towards the model DNA compound 2'-deoxyguanosine 5'-monophosphate (5'-dGMP) is moderate.

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Citations

Oct 17, 2012·Analytical and Bioanalytical Chemistry·Michael Groessl, Christian G Hartinger
Jun 28, 2011·Journal of Computer-aided Molecular Design·Antonella CiancettaUlf Ryde
Apr 1, 2011·Chemical Communications : Chem Comm·Vaishali VajpayeeKi-Whan Chi
May 15, 2010·Dalton Transactions : an International Journal of Inorganic Chemistry·Angela CasiniPaul J Dyson
Aug 7, 2010·Dalton Transactions : an International Journal of Inorganic Chemistry·Johan MattssonBruno Therrien
Jul 7, 2012·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Lydia E H PaulJulien Furrer
Nov 9, 2014·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Lydia E H PaulJulien Furrer
Nov 21, 2014·Organic & Biomolecular Chemistry·Lydia E H PaulJulien Furrer
Jun 7, 2016·Dalton Transactions : an International Journal of Inorganic Chemistry·Stefan RichterEvamarie Hey-Hawkins
Dec 8, 2009·Electrophoresis·Andrei R Timerbaev
Jan 1, 2009·Journal of Analytical Atomic Spectrometry·Alexander E EggerBernhard K Keppler
Jan 4, 2017·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Hannah U HoltkampChristian G Hartinger

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