Elucidation of the role of activin in organogenesis using a multiple organ induction system with amphibian and mouse undifferentiated cells in vitro

Development, Growth & Differentiation
Makoto AsashimaAkira Kurisaki

Abstract

Studies performed over the last century have clarified the mechanisms of organ and tissue formation. Mesoderm formation is one of the most important events in early body pattern determination during embryogenesis. In 1988, we found that activin A has mesoderm-inducing activity. As activin A could induce dorsal mesoderm formation, unlike fibroblast growth factor and bone morphogenetic protein, this factor was thought to be the molecular entity of the Spemann-Mangold organizer. Subsequently, the mechanisms of early embryogenesis have been clarified using molecular biological techniques, resulting in the identification of many genes that are involved in organ and tissue development. This finding that activin A could induce dorsal mesoderm formation spurred research into the application of agents that induce organs and tissues in vitro. In this regard, we have shown that many organ types can be induced by activin A in vitro. Moreover, we have found that other types of organs can be induced by changing the conditions of treatment. To date, more than 20 different types of tissues and organs have been successfully induced from Xenopus undifferentiated cells in vitro. In recent years, we have applied these protocols to mouse embryonic ...Continue Reading

References

Aug 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·M AsashimaK Kinoshita
Jun 1, 1991·Mechanisms of Development·M AsashimaP Hoppe
Apr 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M MurataM Muramatsu
Dec 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·G R Martin
Apr 1, 1995·Molecular Neurobiology·H M Sucov, R M Evans
Nov 1, 1993·Developmental Biology·K KinoshitaM Asashima
Sep 1, 1993·Developmental Biology·A FukuiH Sugino
Oct 1, 1995·Zoological Science·T Ariizumi, M Asashima
Jan 1, 1997·Developmental Biology·G L RadiceR O Hynes
Oct 24, 1997·Development, Growth & Differentiation·T UochiM Asashima
Apr 18, 1998·Development Genes and Evolution·Y MiyanagaM Asashima
May 8, 1998·Development, Growth & Differentiation·H NinomiyaM Asashima
May 27, 1999·International Review of Cytology·M AsashimaG M Malacinski
Mar 23, 2000·Mechanisms of Development·A SatoR Nishinakamura
Jun 1, 2000·Development, Growth & Differentiation·N MoriyaM Asashima
Dec 9, 2000·Developmental Biology·T C ChanM Asashima
Jan 6, 2001·Development, Growth & Differentiation·N MoriyaM Asashima
Apr 10, 2002·Development, Growth & Differentiation·Kenji OsafuneMakoto Asashima
Jun 27, 2002·Biochemical and Biophysical Research Communications·Reiko SatowMakoto Asashima
Nov 9, 2002·Proceedings of the National Academy of Sciences of the United States of America·Miho FurueMakoto Asashima
Nov 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·Yuichi HoriSeung K Kim
Jan 15, 2003·Proceedings of the National Academy of Sciences of the United States of America·Przemyslaw BlyszczukAnna M Wobus
Mar 18, 2003·Genesis : the Journal of Genetics and Development·Toshiyuki MotoikeThomas N Sato
May 20, 2003·Development, Growth & Differentiation·Asako SogameMakoto Asashima
Aug 14, 2003·Biochemical and Biophysical Research Communications·Tomoyo KanekoMakoto Asashima
Aug 29, 2003·Biochemical and Biophysical Research Communications·Jun-ichi KyunoMakoto Asashima
Oct 11, 2003·Current Opinion in Genetics & Development·Koji Okabayashi, Makoto Asashima

❮ Previous
Next ❯

Citations

Jun 22, 2013·Cytokine & Growth Factor Reviews·Francesco Elia MarinoElspeth Gold
Sep 17, 2010·The Journal of Biological Chemistry·Shaoliang LiKiyotoshi Sekiguchi
Jun 23, 2009·Cell Communication and Signaling : CCS·Kunihiro TsuchidaKaoru Inokuchi
Jan 13, 2015·International Journal of Inflammation·Jun YamadaTakeshi Muneta
Jun 20, 2012·FEBS Letters·Thomas D Mueller, Joachim Nickel
Sep 21, 2010·Experimental Gerontology·Craig S Atwood, Richard L Bowen
Apr 13, 2010·Trends in Cardiovascular Medicine·Boni A Afouda, Stefan Hoppler
Apr 1, 2009·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Esther J PearlMarko E Horb
Jun 10, 2010·Journal of Cellular Physiology·Gaetano Leto
Apr 22, 2009·Current Protocols in Stem Cell Biology·Takashi AriizumiMakoto Asashima
Mar 24, 2012·Cell & Bioscience·Richard Kin Ting KamHui Zhao

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Cardiac Regeneration

Cardiac regeneration enables the repair of irreversibly damaged heart tissue using cutting-edge science, including stem cell and cell-free therapy. Discover the latest research on cardiac regeneration here.

© 2022 Meta ULC. All rights reserved