Embolization of left spermatic vein in non-obstructive azoospermic men with varicocele: role of FSH to predict the appearance of ejaculated spermatozoa after treatment

Journal of Endocrinological Investigation
S D'AndreaA Barbonetti

Abstract

Varicocele repair in non-obstructive azoospermia (NOA) was occasionally associated to ejaculated spermatozoa independently from clinical and laboratory measures. We performed a prospective study in infertile men affected by NOA and left side varicocele to find whether or not the appearance of ejaculated spermatozoa after varicocele repair is predicted by baseline measures. Patients with NOA and grade II, or grade III left side varicocele were submitted to hormone analysis and to scrotal color Doppler ultrasound (CDU). Azoospermia was confirmed in 23 patients aged 25-47 years who were than submitted to varicocele repair through a retrograde internal spermatic vein embolization. Patients were re-evaluated after 6 months. Six months after varicocele repair 12 patients (52.2 %) were still azoospermic (Group 1) while 11 patients (47.8 %) reported ejaculated spermatozoa (Group 2) [sperm count: 1.3 × 10(6)/mL; 0.5 × 10(6)/mL-1.6 × 10(6)/mL (median 25th-75th centiles)]. Serum baseline FSH was lower in Group 2 compared to Group 1 (p = 0.012), while no differences between groups were revealed for all other clinical and laboratory parameters. ROC analysis indicated that baseline FSH level predicted the appearance of ejaculated spermatozoa...Continue Reading

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Citations

Dec 19, 2015·Asian Journal of Andrology·Sandro C EstevesAshok Agarwal
Oct 30, 2016·The Journal of Urology·Koji ShiraishiHideyasu Matsuyama
Jul 26, 2018·Andrologia·Settimio D'AndreaSandro Francavilla
Mar 25, 2019·Human Fertility : Journal of the British Fertility Society·Sylvia YanSuks Minhas
Apr 8, 2019·Journal of Endocrinological Investigation·S D'AndreaS Francavilla

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