PMID: 8463032Apr 1, 1993Paper

Embryologic clues to human yolk sac tumors: a review

International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists
F F Nogales

Abstract

Morphological similarities and differences in the developmental structure of the human yolk sac and human yolk sac tumors (HYSTs) are reviewed to determine the histogenesis of the currently recognized multiple tumoral patterns. Although many equivalent histochemical markers, secretory hyaline globules, and hemopoiesis occur in both HYSTs and the secondary human yolk sac (SHYS), few similarities are found in their comparative morphology. For example, HYSTs do not reproduce the characteristic morphology of SHYS with its large, clear cells and endodermal and intracellular tubules; basement membrane is abundant in tumors but only an inapparent and temporary structure in the SHYS; no Schiller-Duval sinuses are found in either primary or secondary human yolk sacs, and the plentiful mesenchymal (mesoblastic) components of tumors are absent in the SHYS except for the collagenous connective tissue that occurs during regression. Unlike the SHYS, which is a terminal structure incapable of polydifferentiation and only rarely develops any somatic structures, HYSTs frequently differentiate tissues of endodermal origin such as intestine, liver, and even lung. The primary human yolk sac is capable of multiple differentiation, both endodermal a...Continue Reading

Citations

Nov 9, 2004·Indian Journal of Pediatrics·Nishat AfrozR S Chana
Jan 10, 2012·Archives of Gynecology and Obstetrics·Maha Arafah, Shaesta N Zaidi
Sep 1, 1996·The American Journal of Surgical Pathology·F F NogalesH R Fulwood
Aug 13, 2005·The American Journal of Surgical Pathology·Francisco F NogalesTalina González
Dec 3, 2014·Seminars in Diagnostic Pathology·Robert H Young
Nov 6, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Robert H Young
Dec 1, 1995·Histopathology·M FukunagaE Ishikawa
Oct 20, 2011·Histopathology·Francisco F NogalesAlina Nicolae
Sep 1, 1995·Baillière's Clinical Obstetrics and Gynaecology·B P Steegers-Theunissen
Oct 19, 2000·Cancer Investigation·K D MillerG P Sutton
May 25, 2002·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Peter W Andrews
Jan 20, 2016·International Journal of Surgical Pathology·Whitney A McCarthy, Ramya P Masand

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