Embryologic features of term fetuses and newborns in CL/Fr mice with special reference to cyanosis

The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association
S KadowakiT Tanimura

Abstract

The objective of this study was to clarify the embryologic features of CL/Fr mice in relation to cyanosis. Orofacial examinations were conducted on 18-day-old term fetuses and newborns. Except for open eyelids in a few cases, all of the external abnormalities in this strain were cleft lip and/or palate (CLP). The CLP incidence in term fetuses was 28.4%. The body and placental weights were not different between CLP(+) and CLP(-) fetuses. Several types of CLP were found; the most frequent was bilateral complete CLP (60%) followed by left complete (16%). Bilateral complete CL, which is the most severe CL type, was associated with poorly developed secondary palate and wide cleft. In newborns, 39.4 % of CLP(+) mice showed cyanosis, where no CLP(-) mice had such signs. The body weight of cyanotic mice with CLP was significantly lighter than that of noncyanotic mice with CLP. Cyanotic mice had severe types of CLP and unelevated palatal shelves. We suggest that mechanical airway obstruction may be one of the causes of cyanosis in newborn CL/Fr mice.

References

Mar 1, 1987·Kōkūbyō Gakkai zasshi. The Journal of the Stomatological Society, Japan·S Asada
Feb 1, 1963·Developmental Biology·D G Trasler, F C Fraser
May 1, 1982·The American Journal of Anatomy·G MillicovskyM C Johnston
Apr 1, 1980·Teratology·D M Juriloff, F C Fraser
Feb 1, 1995·Mammalian Genome : Official Journal of the International Mammalian Genome Society·D M Juriloff, D G Mah
Jul 1, 1954·Plastic and Reconstructive Surgery·M L CANICK

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Citations

Sep 8, 2001·Plastic and Reconstructive Surgery·S H KooJ H Grant
Oct 3, 2008·Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery·Manabu NakazawaYasuteru Muragaki
Jun 9, 2009·Sleep Medicine Reviews·Joanna E MacLeanKaren Waters
Sep 24, 2004·Journal of Dental Research·Y SasakiY Taya

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