Embryonic and larval expression of zebrafish voltage-gated sodium channel alpha-subunit genes

Developmental Dynamics : an Official Publication of the American Association of Anatomists
Alicia E NovakAngeles B Ribera

Abstract

Whereas it is known that voltage-gated calcium channels play important roles during development, potential embryonic roles of voltage-gated sodium channels have received much less attention. Voltage-gated sodium channels consist of pore-forming alpha-subunits (Na(v)1) and auxiliary beta-subunits. Here, we report the embryonic and larval expression patterns for all eight members of the gene family (scna) coding for zebrafish Na(v)1 proteins. We find that each scna gene displays a distinct expression pattern that is temporally and spatially dynamic during embryonic and larval stages. Overall, our findings indicate that scna gene expression occurs sufficiently early during embryogenesis to play developmental roles for both muscle and nervous tissues.

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Citations

Jul 11, 2006·Journal of Molecular Evolution·Alicia E NovakAngeles B Ribera
Aug 10, 2007·Journal of Biomedical Science·Yau-Hung ChenHuey-Jen Tsay
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