Embryonic and postnatal development in experimental tryptophan deprived rats. A preliminary study.

Journal of Molecular Histology
R Imbesi, P Castrogiovanni

Abstract

An ontogenetic and endocrinological study has been designed on developing rats in uterus of mothers tryptophan deprived at day 1 (exp. 1) and day 14.5 (exp. 2) of conception to verify the supposed determining role of the serotoninergic system (SS) in sexual differentiation in mammals. Tryptophan-free feeding has been pursued uninterruptedly in the litter after birth, during lactation and postnatal development. Tryptophan-free pregnant rats were obtained by exclusion of tryptophan sources from chow. In both exp. 1 and exp. 2 the litter showed at birth a significant physical under evolution, that worsened, during post-natal development, to a much more marked dwarfism in exp. 1 pups. At 30 days postnatal age, whereas the female exp. 1 rats showed a right-timed onset of puberty, neither descensus of the testes nor spermatogenesis could be observed in the male rats of the same experiment. Endocrinologically the males showed a significant reduction of plasma FSH levels, but also a slight increase of those of LH. Moreover, a marked hypoandrogenism and a severe hypoprolactinemia characterized the males of this group. Hypoprolactinemia was the major endocrinological finding also in the female litter, which, however, at 30 days p.n. age ...Continue Reading

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Citations

May 7, 2013·European Journal of Nutrition·Paola CastrogiovanniRosa Imbesi
Sep 23, 2009·Anatomia, histologia, embryologia·R ImbesiP Castrogiovanni
Apr 9, 2015·Acta histochemica·Giuseppe MusumeciRosa Imbesi
Apr 5, 2020·Nutrients·Soranobu NinomiyaHisashi Tsurumi

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