PMID: 3771649Oct 1, 1986Paper

Embryonic avian cornea contains layers of collagen with greater than average stability

The Journal of Cell Biology
T F LinsenmayerJ M Fitch

Abstract

A unique morphological feature of the embryonic avian cornea is the uniformity of its complement of striated collagen fibrils, each of which has a diameter of 25 nm. We have asked whether this apparent morphological uniformity also reflects an inherent uniformity of the structural and physical properties of these fibrils. For this we have examined the in situ thermal stability of the type I collagen within these fibrils. Corneal tissue sections were reacted at progressively higher temperatures with conformation-dependent monoclonal antibodies directed against the triple-helical domain of the type I collagen molecule. These studies show that the cornea contains layers of collagen fibrils with greater than average stability. The two most prominent of these extend uninterrupted across the entire width of the cornea, and then appear to insert into thick bundles of scleral collagen, which in turn appear to insert into the scleral ossicles, a ring of bony plates which circumscribe the sclera of the avian eye. Once formed, the bands may act to stabilize the shape of the cornea or, conversely, to alter it during accommodation.

References

Aug 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·T F LinsenmayerC D Little
Sep 1, 1977·The Journal of Cell Biology·J B Bard, K Higginson
Feb 1, 1985·The Journal of Cell Biology·T M Schmid, T F Linsenmayer
May 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·J M FitchT F Linsenmayer

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Citations

Aug 1, 1991·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·G MajmudarJ Bonadio
Sep 24, 2002·Journal of Cellular Biochemistry·Blanche B YoungDavid E Birk
Oct 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·Q A ChenT F Linsenmayer
Mar 1, 1988·The Journal of Cell Biology·D E BirkT F Linsenmayer
Apr 1, 1990·The Journal of Cell Biology·J M FitchT F Linsenmayer
Jan 1, 1997·Annual Review of Entomology·M J Lehane
Sep 9, 2008·Progress in Retinal and Eye Research·Jeffrey W Ruberti, James D Zieske
Nov 3, 2005·Developmental Biology·Peter Y LwigaleMarianne Bronner-Fraser
Jan 1, 1991·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·G E MarshallW R Lee
Jun 4, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Andrew J Quantock, Robert D Young
May 1, 1996·Developmental Dynamics : an Official Publication of the American Association of Anatomists·M K GordonJ M Fitch
May 27, 2006·The Journal of Biological Chemistry·Manuel KochMarion K Gordon
Dec 10, 2002·Experimental Eye Research·Jeffrey K MarchantDavid E Birk

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