PMID: 9662830Jul 15, 1998Paper

Embryonic brain-gonadal axis in temperature-dependent sex determination of reptiles: a role for P450 aromatase (CYP19)

The Journal of Experimental Zoology
P Jeyasuria, A R Place

Abstract

Sex determination in egg-laying amniotes may be fundamentally different from that of placental mammals. The mammalian ovary differentiates normally in the absence of estrogen, whereas estrogen seems to be crucial for proper ovarian development in birds, reptiles, and lower vertebrates. Estrogens are produced normally by the biosynthetic conversion of androgens by the enzyme aromatase (CYP19), which is the sole mediator of this reaction. Aromatase inhibitors are capable of reversing females to males in turtles and chickens; therefore, a role for aromatase as the female sex determinant has been postulated for species in which sex determination is temperature-dependent. The entire aromatase coding sequence (1,509 base pairs) from adult terrapin ovaries was cloned, and Northern analysis indicates a single transcript (2.4 kb) for adult ovaries, whereas male and female brains express a 2.4-kb as well as a 9.6-kb transcript. Using a sensitive (attomole sensitivity) competitive RT-PCR technique, aromatase transcript abundance was quantified during embryonic development for embryos treated with and without estrogen. Aromatase is transcribed, well before the temperature-sensitive, (stage 12), at both male and female temperatures in the b...Continue Reading

References

Apr 1, 1992·General and Comparative Endocrinology·V A Lance, M H Bogart
Feb 1, 1992·Biology of Reproduction·J D Wilson
Jan 24, 1992·Science·A Elbrecht, R G Smith
Aug 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·G Desvages, C Pieau
Jun 1, 1991·The Quarterly Review of Biology·F J Janzen, G L Paukstis
Mar 1, 1991·Archives of Biochemistry and Biophysics·M TerashimaY Shizuta
Mar 1, 1991·General and Comparative Endocrinology·D CrewsT Wibbels
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·C J CorbinE R Simpson
Oct 31, 1988·Biochemical and Biophysical Research Communications·N Harada
Jun 1, 1988·General and Comparative Endocrinology·J J BullD Crews
Oct 7, 1987·Journal of Theoretical Biology·M H Bogart
Dec 1, 1986·General and Comparative Endocrinology·W H Gutzke, J J Bull
Jun 1, 1995·The Journal of Steroid Biochemistry and Molecular Biology·K TodaY Shizuta
Sep 15, 1994·The Journal of Experimental Zoology·A M CoriatP T Sharpe
Sep 15, 1994·The Journal of Experimental Zoology·J R SpotilaN F Kaufer
Sep 15, 1994·The Journal of Experimental Zoology·P JeyasuriaA R Place
Sep 1, 1993·Peptides·A Rodriguez-BelloJ M Conlon
Jul 1, 1993·Differentiation; Research in Biological Diversity·T WibbelsD Crews
Feb 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·C M HaqqM A Weiss
Mar 1, 1993·The Journal of Steroid Biochemistry and Molecular Biology·E R SimpsonC R Mendelson
May 1, 1993·The Journal of Experimental Zoology·B E VietsD Crews
May 25, 1993·Nucleic Acids Research·V LaudetH Clevers
Aug 30, 1995·Molecular and Cellular Endocrinology·C J CorbinA J Conley
Jul 1, 1996·Differentiation; Research in Biological Diversity·M DorizziC Pieau
Aug 1, 1996·Trends in Biochemical Sciences·M H WernerG M Clore

❮ Previous
Next ❯

Citations

Nov 12, 2005·Reproductive Biology and Endocrinology : RB&E·Jonas von Hofsten, Per-Erik Olsson
Feb 11, 2010·Sexual Development : Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation·T Rhen, A Schroeder
Mar 21, 2017·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Maria Michela PallottaTeresa Capriglione
Apr 12, 2005·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Jin Young ChoiSe Jae Kim
Jul 20, 2000·The Journal of Experimental Zoology·M PavlidisM Kentouri
Dec 19, 2001·The Journal of Experimental Zoology·A R PlaceP Jeyasuria
Jul 15, 1998·The Journal of Experimental Zoology·T WibbelsR LeBoeuf
Jul 27, 2001·The Journal of Experimental Zoology·L O AfonsoR Terezinha de Oliveira
Nov 30, 2006·International Journal of Obesity : Journal of the International Association for the Study of Obesity·J B Young
Jul 13, 2002·The Journal of Experimental Zoology·Rachel M BowdenCraig E Nelson
Aug 26, 2009·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Shuhei NakamuraMinoru Tanaka
Jul 14, 2010·Journal of Experimental Zoology. Part A, Ecological Genetics and Physiology·Masahisa Nakamura
Feb 7, 2020·Biological Reviews of the Cambridge Philosophical Society·Meghan A CastelliClare E Holleley
May 16, 2019·The European Journal of Neuroscience·Rafael GenarioAllan V Kalueff

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.