Embryonic cell-cell adhesion: a key player in collective neural crest migration

Current Topics in Developmental Biology
Elias H Barriga, Roberto Mayor

Abstract

Cell migration is essential for morphogenesis, adult tissue remodeling, wound healing, and cancer cell migration. Cells can migrate as individuals or groups. When cells migrate in groups, cell-cell interactions are crucial in order to promote the coordinated behavior, essential for collective migration. Interestingly, recent evidence has shown that cell-cell interactions are also important for establishing and maintaining the directionality of these migratory events. We focus on neural crest cells, as they possess extraordinary migratory capabilities that allow them to migrate and colonize tissues all over the embryo. Neural crest cells undergo an epithelial-to-mesenchymal transition at the same time than perform directional collective migration. Cell-cell adhesion has been shown to be an important source of planar cell polarity and cell coordination during collective movement. We also review molecular mechanisms underlying cadherin turnover, showing how the modulation and dynamics of cell-cell adhesions are crucial in order to maintain tissue integrity and collective migration in vivo. We conclude that cell-cell adhesion during embryo development cannot be considered as simple passive resistance to force, but rather participat...Continue Reading

Citations

May 25, 2016·Tissue Engineering. Part C, Methods·Chun LiuChristina Chan
Nov 23, 2016·Molecular and Cellular Neurosciences·Gianfranco GennariniAndrew J W Furley
May 4, 2018·Wiley Interdisciplinary Reviews. Developmental Biology·Crystal D Rogers, Shuyi Nie
Nov 27, 2018·Annual Review of Genetics·András Szabó, Roberto Mayor
Dec 7, 2018·Zygote : the Biology of Gametes and Early Embryos·Xiao-Tan ZhangXuesong Yang
Jan 8, 2020·Nature Cell Biology·Pavlo G GritsenkoPeter Friedl
Jan 18, 2020·Biomolecules·Magalí Rey-CamposAntonio Figueras
Mar 3, 2017·Genesis : the Journal of Genetics and Development·Lisa A Taneyhill, Andrew T Schiffmacher
Sep 23, 2018·Nature Communications·Maria KotiniRoberto Mayor
Apr 30, 2020·International Journal of Molecular Sciences·Xiao LinAirong Qian
Apr 7, 2019·Cancer Research·Kacey VanderVorstKermit L Carraway
Aug 14, 2019·Current Opinion in Genetics & Development·Frank Macabenta, Angelike Stathopoulos
Mar 1, 2020·Annual Review of Cancer Biology·Alexandre Francou, Kathryn V Anderson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.

Adherens Junctions

An adherens junction is defined as a cell junction whose cytoplasmic face is linked to the actin cytoskeleton. They can appear as bands encircling the cell (zonula adherens) or as spots of attachment to the extracellular matrix (adhesion plaques). Adherens junctions uniquely disassemble in uterine epithelial cells to allow the blastocyst to penetrate between epithelial cells. Discover the latest research on adherens junctions here.

Biophysics of Adhesion

Alterations in cell adhesion can disrupt important cellular processes and lead to a variety of diseases, including cancer and arthritis. It is also essential for infectious organisms, such as bacteria or viruses, to cause diseases. Understanding the biophysics of cell adhesion can help understand these diseases. Discover the latest research on the biophysics of adhesion here.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Related Papers

Current Opinion in Cell Biology
Eric Theveneau, Roberto Mayor
Sub-cellular Biochemistry
Sandrine Etienne-Manneville
Progress in Molecular Biology and Translational Science
Lisa A Taneyhill, Andrew T Schiffmacher
© 2022 Meta ULC. All rights reserved