PMID: 7537810Feb 1, 1995Paper

Embryonic cell death patterns associated with nitrofen-induced congenital diaphragmatic hernia

Journal of Pediatric Surgery
A J AllesJ J Schnitzer

Abstract

The offspring of pregnant Sprague-Dawley rats exposed to nitrofen on gestational day 9.5 develop left-sided congenital diaphragmatic hernia (CDH). Twenty-four hours after treatment, on day 10.5, supravital staining with Nile blue sulfate and histological examination showed bilateral excessive cell death in cervical somites 2 through 4. After 48 hours, on day 11.5, cell death was absent in the cervical somites but was apparent in the mesoderm adjacent to the somites in the septum transversum and in the developing sympathetic ganglia adjacent to the dorsal aortae. Cell death was not apparent in the foregut or lung primordia on either day 10.5 or 11.5. The incidence of nitrofen-exposed embryos with such patterns of cell death closely paralleled that of left-sided CDH in similarly treated day 21.5 fetuses. Control animals treated with olive oil had normal programmed cell death patterns in the regions of interest and had no evidence of CDH on day 21.5. It is possible that these patterns of excessive cell death early in gestation may play a role in the genesis of diaphragmatic hernia. Mesoderm derived from cervical somites 3 through 5 contributes to the diaphragmatic anlage and forms the major portion of the muscle of the diaphragm. ...Continue Reading

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Citations

Feb 18, 2006·Theoretical Biology & Medical Modelling·Jason C Fisher, Lawrence Bodenstein
Nov 28, 2009·Nutrition Reviews·Leonardus W J E BeurskensRégine P M Steegers-Theunissen
May 10, 2011·Revue des maladies respiratoires·A LabbéP-J Déchelotte
May 26, 2009·European Journal of Medical Genetics·M KlaassensD Tibboel
Jun 16, 2010·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·David E KlingDavid S Newburg
Aug 28, 2009·Birth Defects Research. Part A, Clinical and Molecular Teratology·Robin D ClugstonJohn J Greer
Jan 26, 2000·Journal of Pediatric Surgery·E C JesudasonP D Losty
Jul 19, 2005·American Journal of Surgery·John R GoscheScott C Boulanger
Dec 8, 2004·Toxicology in Vitro : an International Journal Published in Association with BIBRA·D E KlingJ J Schnitzer
Apr 17, 2007·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·David E Kling, Jay J Schnitzer
Sep 27, 2007·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Jeremy T AidlenDavid E Kling
Jun 19, 2001·Annals of Plastic Surgery·J M AcostaD Warburton
Aug 1, 1997·Journal of Applied Physiology·D W Allan, J J Greer

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