Embryonic Cerebrospinal Fluid Increases Neurogenic Activity in the Brain Ventricular-Subventricular Zone of Adult Mice

Frontiers in Neuroanatomy
Maria I AlonsoA Gato

Abstract

Neurogenesis is a very intensive process during early embryonic brain development, becoming dramatically restricted in the adult brain in terms of extension and intensity. We have previously demonstrated the key role of embryonic cerebrospinal fluid (CSF) in developing brain neurogenic activity. We also showed that cultured adult brain neural stem cells (NSCs) remain competent when responding to the neurogenic influence of embryonic CSF. However, adult CSF loses its neurogenic inductive properties. Here, by means of an organotypic culture of adult mouse brain sections, we show that local administration of embryonic CSF in the subventricular zone (SVZ) niche is able to trigger a neurogenic program in NSCs. This leads to a significant increase in the number of non-differentiated NSCs, and also in the number of new neurons which show normal migration, differentiation and maturation. These new data reveal that embryonic CSF activates adult brain NSCs, supporting the previous idea that it contains key instructive components which could be useful in adult brain neuroregenerative strategies.

References

Apr 1, 1991·Journal of Neuroscience Methods·L StoppiniD Muller
May 29, 2003·Canadian Journal of Physiology and Pharmacology·Jaleel A MiyanMahjuib Zendah
Mar 9, 2004·Neuron·Arturo Alvarez-Buylla, Daniel A Lim
Mar 25, 2004·Journal of Experimental Zoology. Part A, Comparative Experimental Biology·A GatoJ A Moro
Apr 2, 2005·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Angel GatoC Martín
Nov 16, 2005·Proteomics·Carolina ParadaDavid Bueno
Dec 2, 2005·The Journal of Comparative Neurology·Alfredo Quiñones-HinojosaArturo Alvarez-Buylla
Jan 18, 2006·Science·Kazunobu SawamotoArturo Alvarez-Buylla
Jun 16, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Toru YamashitaKazunobu Sawamoto
Oct 19, 2006·Current Opinion in Cell Biology·Florian T Merkle, Arturo Alvarez-Buylla
Aug 19, 2007·Journal of Proteome Research·Mauro D ZappaterraBryan A Ballif
Oct 17, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Justin D LathiaCharles Ffrench-Constant
Feb 26, 2008·Cell·Chunmei ZhaoFred H Gage
Dec 11, 2008·Journal of Visualized Experiments : JoVE·Li Liu, Karen Duff
Jan 3, 2009·Neuroscience Research·Naoko Kaneko, Kazunobu Sawamoto
Jun 23, 2009·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·C MartinA Gato
Jun 27, 2009·Annual Review of Neuroscience·Arnold Kriegstein, Arturo Alvarez-Buylla
Nov 17, 2009·Neurobiology of Disease·Steven G Kernie, Jack M Parent
Jan 26, 2010·Neuropharmacology·Manavendra PathaniaAngélique Bordey
Mar 9, 2011·Neuron·Maria K LehtinenChristopher A Walsh
May 20, 2011·Developmental Dynamics : an Official Publication of the American Association of Anatomists·M I AlonsoA Gato
Aug 2, 2011·Annual Review of Cell and Developmental Biology·Maria K Lehtinen, Christopher A Walsh
Mar 15, 2012·Cellular and Molecular Life Sciences : CMLS·Mauro W Zappaterra, Maria K Lehtinen
Jun 8, 2012·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Yonggang MaBin He
Dec 12, 2012·Mechanisms of Development·Konstantin KhodosevichHannah Monyer
Jul 12, 2013·Journal of Cell Science·Fernando J Perez-AsensioEsther Pozas
May 28, 2014·The International Journal of Developmental Biology·Mary E DesmondAngel Gato
Aug 29, 2014·Croatian Medical Journal·Angel GatoMary E Desmond
Sep 17, 2014·Trends in Neurosciences·Daniel A Lim, Arturo Alvarez-Buylla
Jul 16, 2015·Nature Reviews. Neuroscience·Melody P LunMaria K Lehtinen
Aug 18, 2016·Frontiers in Neuroscience·Eun Hyuk ChangFrancis G Szele
May 4, 2017·MethodsX·Jared SchommerOthman Ghribi

❮ Previous
Next ❯

Citations

Nov 19, 2019·Developmental Dynamics : an Official Publication of the American Association of Anatomists·F LamusM I Alonso
Aug 22, 2018·Neural Regeneration Research·Mª Isabel Alonso, Angel Gato
Jul 9, 2020·International Journal of Molecular Sciences·Karol Kaiser, Vitezslav Bryja
Jan 25, 2021·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Nishit MummareddyAkshitkumar M Mistry
Jul 9, 2021·Fluids and Barriers of the CNS·Vijay KumarJaebong Kim
Oct 17, 2019·Seminars in Cell & Developmental Biology·David BuenoJaleel Miyan

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.