Embryonic development in the primitive bilaterian Neochildia fusca: normal morphogenesis and isolation of POU genes Brn-1 and Brn-3

Development Genes and Evolution
Nallur B RamachandraVolker Hartenstein

Abstract

Neochildia fusca is a member of the taxon Acoela, a group of flatworms that, according to some recent molecular phylogenetic analyses, are distinct from other flatworms and constitute a basal branch with a sister taxon relationship to the rest of the Bilateria. In this paper, we analyze early neural development in this species and report the sequence and expression of two Pit-Oct-Unc (POU) genes, NeocBrn-1 and NeocBrn-3. Homologs of these highly conserved genes play a role in neural fate determination in vertebrates, Drosophila and Caenorhabditis elegans. Acoels, including Neochildia, have a unique invariant pattern of early cleavage called duet spiral cleavage. In subsequent cell divisions descendants of the first three micromere duets form an outer layer of epidermal and neural progenitors surrounding the meso/endoderm progenitors, which are themselves descended from the macromere duet 4A, B and the micromere duet 4a, b. Organ formation begins at mid-embryonic stages with the epidermal primordium adopting a ciliated epithelial shape. Sub-epidermally, a bilaterally symmetric brain primordium can be seen at the anterior pole. Laterally and posteriorly, myoblasts form a thin layer underneath the epidermis. In late embryos and ju...Continue Reading

Citations

Dec 6, 2006·Development Genes and Evolution·Bernhard EggerReinhard Rieger
Jun 16, 2010·Development Genes and Evolution·Amandine BeryVolker Hartenstein
Nov 13, 2012·Development Genes and Evolution·Xavier BaillyVolker Hartenstein
Jul 31, 2003·Current Opinion in Genetics & Development·Alejandro Sánchez Alvarado
Feb 28, 2013·Nature Communications·Hiroaki NakanoMichael C Thorndyke
Jan 15, 2008·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Rudolf A Raff
May 6, 2009·Development Genes and Evolution·Arnon D JurbergHenrique L Lenzi
Sep 24, 2004·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Jaume Baguñà, Marta Riutort
May 18, 2011·Glia·Daniel K Hartline
Nov 26, 2015·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Brenda GavilánPedro Martínez
Feb 25, 2015·Developmental Cell·Volker Hartenstein, Angelika Stollewerk
Dec 19, 2017·BMC Evolutionary Biology·Hiroaki NakanoHisanori Kohtsuka
Aug 14, 2018·Genome Biology and Evolution·Michael BrauchleSimon G Sprecher
Aug 2, 2003·Nature Reviews. Neuroscience·Nicholas D Holland
May 17, 2019·Cell and Tissue Research·B GavilánP Martinez
Aug 8, 2018·Neurogenesis·Maria Del Mar De Miguel-BonetVolker Hartenstein

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